The synthesis, characterisation and cytotoxicity of bisintercalating (2,2′:6′,2"-terpyridine)platinum(II) complexes
The synthesis, characterisation and cytotoxicity of bisintercalating (2,2′:6′,2"-terpyridine)platinum(II) complexes
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DOI：
10.1039/c4dt02773f
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发表时间：
2015-01-01
影响因子：
4
通讯作者：
Aldrich-Wright, Janice R.
中科院分区：
文献类型：
--
作者：
Harper, Benjamin W. J.;Aldrich-Wright, Janice R.
双核（2，2 '：6'，2 "-三联吡啶）铂（II）（PtTerpy）配合物通过基于硫醇或吡啶的连接体来合成。所有的中间体和得到的配合物的特征在于使用的组合的H-1和Pt-195 NMR，二维H-1相关光谱（NOSY/COSY），二维H-1/Pt-195杂原子多重键相关光谱（HMQC），元素分析和电喷雾电离质谱（ESI-MS）。测定了配合物对人卵巢癌细胞A2780及其顺铂耐药亚系A2780cis以及小鼠白血病细胞L1210的细胞毒性。
Dinuclear (2,2':6',2 ''-terpyridine) platinum(II) (PtTerpy) complexes were synthesised by tethering either thiol or pyridine based linkers. All intermediates and resulting complexes were characterised using a combination of H-1 and Pt-195 NMR, two-dimensional H-1 correlation spectroscopy (NOSY/COSY), two-dimensional H-1/Pt-195 heteronuclear multiple bond correlation spectroscopy (HMQC), elemental analysis and electrospray ionisation mass spectrometry (ESI-MS). The cytotoxicity of the complexes was determined against human A2780 ovarian carcinoma cells and its cisplatin-resistant sub-line A2780cis, as well as L1210 murine leukemia cells.