IMMUNOSUPPRESSION INVIVO BY A SOLUBLE FORM OF THE CTLA-4 T-CELL ACTIVATION MOLECULE
IMMUNOSUPPRESSION INVIVO BY A SOLUBLE FORM OF THE CTLA-4 T-CELL ACTIVATION MOLECULE
复制标题
DOI：
10.1126/science.1496399
复制
发表时间：
1992-08-07
期刊：
影响因子：
56.9
通讯作者：
TEPPER, MA
中科院分区：
文献类型：
--
作者：
LINSLEY, PS;WALLACE, PM;TEPPER, MA
在体外，当抗原呈递细胞表面的B7分子与T细胞表面分子CD28和细胞毒性T淋巴细胞相关抗原4（CTLA - 4）结合时，会产生一种激活T细胞的共刺激信号。CTLA4Ig是CTLA - 4胞外结构域的一种可溶性形式，能高亲和力地结合B7。在体内使用CTLA4Ig治疗可抑制T细胞依赖的针对绵羊红细胞或钥孔血蓝蛋白的抗体反应。大剂量的CTLA4Ig可抑制对二次免疫的反应。因此，B7的共刺激作用对体内的体液免疫反应很重要，并且干扰共刺激作用可能对治疗抗体介导的自身免疫性疾病有用。
In vitro, when the B7 molecule on the surface of antigen-presenting cells binds to the T cell surface molecules CD28 and CTLA-4, a costimulatory signal for T cell activation is generated. CTLA4Ig is a soluble form of the extracellular domain of CTLA-4 and binds B7 with high avidity. CTLA4Ig treatment in vivo suppressed T cell-dependent antibody responses to sheep erythrocytes or keyhole limpet hemocyanin. Large doses of CTLA4Ig suppressed responses to a second immunization. Thus, costimulation by B7 is important for humoral immune responses in vivo, and interference with costimulation may be useful for treatment of antibody-mediated autoimmune disease.