Different genetic characteristics of Plasmodium falciparum isolates collected during successive clinical malaria episodes in Senegalese children
Different genetic characteristics of Plasmodium falciparum isolates collected during successive clinical malaria episodes in Senegalese children
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DOI：
10.4269/ajtmh.1996.54.632
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发表时间：
1996-06-01
影响因子：
3.3
通讯作者：
MercereauPuijalon, O
中科院分区：
文献类型：
--
作者：
Contamin, H;Fandeur, T;MercereauPuijalon, O
一个狭窄的流行病学调查期间进行了为期四个月的密集疟疾传播的Dielmo，一个holoendemic塞内加尔村庄。纵向临床和寄生虫学随访表明，临床疟疾发作总是发生在寄生虫密度突然增加后。恶性疟原虫寄生虫的聚合酶链反应分析进行了纵向收集的血液样本从10名儿童谁经历了几个临床发作在此期间。我们的数据显示，在这个村庄传播的寄生虫的遗传多样性非常大。每个孩子经历的连续临床发作是由遗传上不同的寄生虫种群引起的，这些寄生虫种群最近接种并以明显不受限制的方式繁殖。重要的是，在无症状携带阶段检测到的寄生虫种群的遗传特征与引起临床发作的寄生虫种群不同，这表明控制这些儿童体内寄生虫生长的各种因素具有菌株特异性。
A narrow epidemiologic survey was conducted during a four-month period of intense malaria transmission in Dielmo, a holoendemic Senegalese village. Longitudinal clinical and parasitologic follow-up indicate that clinical malaria episodes always occurred after an abrupt increase in parasite densities. Polymerase chain reaction analysis of Plasmodium falciparum parasites was carried out in blood samples collected longitudinally from 10 children who had experienced several clinical episodes during this period. Our data show that the genetic diversity of the parasites circulating in this village is very large. The successive clinical episodes experienced by each child were caused by genetically distinct parasite populations that were recently inoculated and multiplied in an apparently unrestricted manner. importantly, the genetic characteristics of the parasite populations detected during phases of asymptomatic carriage differed from those causing a clinical episode, suggesting that the various factors that control of parasite growth in these children are strain-specific.