The fate of benzoic acid in various species.
The fate of benzoic acid in various species.
复制标题
苯甲酸在不同物种中的命运。
作者：
J. Bridges;M. R. French;Richard L. Smith;R. T. Williams
1. 对人和 20 种其他动物体内口服[(14)C]苯甲酸的尿排泄进行了检查。 2.在50mg/kg剂量下，啮齿动物（大鼠、小鼠、豚鼠、金黄地鼠、草原旅鼠和沙鼠）、兔子、猫和卷尾猴将苯甲酸几乎全部以马尿酸的形式排出（24小时排泄的95-100%）。 3. 人1mg/kg剂量和恒河猴20mg/kg剂量苯甲酸全部以马尿酸形式排出体外。 4. 50mg/kg苯甲酸以马尿酸形式排出，约占松鼠猴、猪、狗、雪貂、刺猬和鸽子24小时排泄量的80%，另外20%以苯甲酰葡萄糖醛酸和苯甲酸形式排出，后者可能是前者分解产生的。 5、当雪貂体内苯甲酸剂量增加至200mg/kg时，苯甲酰葡萄糖醛酸的排泄比例增加，马尿酸的排泄比例减少。这种情况在兔子身上没有发生，兔子排出的 200mg/kg 几乎全部以马尿酸的形式排出。刺猬和雪貂对苯甲酸的代谢似乎与狗相似。 6. 印度果蝠仅产生微量马尿酸，并且苯甲酸的甘氨酸结合可能存在缺陷。该动物（剂量50mg/kg）的主要代谢物是苯甲酰葡萄糖醛酸。 7. 鸡、侧颈龟和壁虎主要将苯甲酸转化为鸟尿酸，但这三个物种也分泌少量的马尿酸。
1. The urinary excretion of orally administered [(14)C]benzoic acid in man and 20 other species of animal was examined. 2. At a dose of 50mg/kg, benzoic acid was excreted by the rodents (rat, mouse, guinea pig, golden hamster, steppe lemming and gerbil), the rabbit, the cat and the capuchin monkey almost entirely as hippuric acid (95-100% of 24h excretion). 3. In man at a dose of 1mg/kg and the rhesus monkey at 20mg/kg benzoic acid was excreted entirely as hippuric acid. 4. At 50mg/kg benzoic acid was excreted as hippuric acid to the extent of about 80% of the 24h excretion in the squirrel monkey, pig, dog, ferret, hedgehog and pigeon, the other 20% being found as benzoyl glucuronide and benzoic acid, the latter possibly arising by decomposition of the former. 5. On increasing the dose of benzoic acid to 200mg/kg in the ferret, the proportion of benzoyl glucuronide excreted increased and that of hippuric acid decreased. This did not occur in the rabbit, which excreted 200mg/kg almost entirely as hippuric acid. It appears that the hedgehog and ferret are like the dog in respect to their metabolism of benzoic acid. 6. The Indian fruit bat produced only traces of hippuric acid and possibly has a defect in the glycine conjugation of benzoic acid. The main metabolite in this animal (dose 50mg/kg) was benzoyl glucuronide. 7. The chicken, side-necked turtle and gecko converted benzoic acid mainly into ornithuric acid, but all three species also excreted smaller amounts of hippuric acid.