Analysis of Human Papillomavirus Infection in 16,320 Patients From a Gynecology Clinic in Central South China
Analysis of Human Papillomavirus Infection in 16,320 Patients From a Gynecology Clinic in Central South China
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中南地区妇科门诊16320例人乳头瘤病毒感染情况分析
DOI：
10.1097/lgt.0000000000000243
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发表时间：
2016-10-01
影响因子：
3.7
通讯作者：
Xue, Min
中科院分区：
文献类型：
--
作者：
Xiao, Song S.;Fan, Jie L.;Xue, Min
目的探讨人乳头瘤病毒（HPV）持续感染与宫颈病变的关系。方法回顾性分析2010年10月至2011年12月在我院就诊的100例宫颈癌患者的HPV感染情况，比较不同年龄组HPV亚型感染率，探讨HPV持续感染与宫颈细胞学检查的关系。最常见的基因型是HPV 52、HPV 16、HPV 58、CP 8304和HPV 53。60岁以上的女性中高危HPV的总体患病率最高，30至39岁的女性中患病率最低。不同年龄组之间的低风险HPV患病率无显著差异（p = 0.693）。初检阳性者1年后HPV清除率为87.65%。非持续阳性和持续阳性（PP）组之间高危或低危HPV亚型的构成比无显著差异（p = 0.545）。相反，这两组之间单一或多型HPV感染的构成比有显著差异（p <0.05）。PP组中最常见的亚型为HPV 16、52、58、CP 8304和33。PP组中意义不明的不典型鳞状细胞、高度鳞状上皮内病变和鳞状细胞癌的发生率显著增加（p <0.05）。本地区应特别重视HPV16、52、58的防治。
Objective This study aimed to investigate the relationship between persistent human papillomavirus (HPV) infection and cervical lesion.Methods Clinical data of 16,320 patients who visited our clinic between January 2009 and December 2013 were collected. Retrospective analysis was performed to analyze the overall HPV infection and compare the infection rates of different subtypes among different age groups, to reveal the relationship between persistent HPV infection and cervical cytology.Results The overall prevalence of HPV was 26.54%. The most common genotypes were HPV 52, HPV 16, HPV 58, CP8304, and HPV 53. The highest overall high-risk HPV prevalence was found in women older than 60 years, and the lowest prevalence was found in women between the ages of 30 and 39 years. There was no significant difference in low-risk HPV prevalence among different age groups (p = .693). The HPV clearance rate after 1 year among those with initial positive test was 87.65%. The constituent ratios of high- or low-risk HPV subtypes were not significantly different (p = .545) between nonpersistent-positive and persistent-positive (PP) groups. Conversely, the constituent ratios of singe- or multi-type HPV infection were significantly different (p < .05) between these 2 groups. The most common subtypes in PP group were HPV 16, 52, 58, CP8304, and 33. The occurrence rates of atypical squamous cells of undetermined significance, high-grade squamous intraepithelial lesion, and squamous cell carcinoma in the PP group significantly increased (p < .05).Conclusions Persistent HPV infections are mainly caused by multiple types of HPV and high-risk HPV. Our region should particularly pay attention to the prevention and treatment of HPV 16, 52, and 58.