Naloxone injections into CA3 disrupt pattern completion associated with relapse from cocaine seeking.
Naloxone injections into CA3 disrupt pattern completion associated with relapse from cocaine seeking.
复制标题
DOI：
10.1002/hipo.22570
复制
发表时间：
2016-07
期刊：
影响因子：
3.5
通讯作者：
Keefe K
中科院分区：
文献类型：
--
作者：
Kesner RP;Kirk RA;Clark JK;Moore A;Keefe K
本研究的目的是评估在何种程度上的模式完成过程中运作的线索诱导的可卡因寻求行为的复发。使用位置偏好任务的一种新的线索偏好版本，大鼠被给予可卡因或盐水，这导致了对可卡因配对线索的偏好。在禁欲21天后和偏好测试之前，对于一组，将PBS或纳洛酮注射到海马的CA3亚区中，对于第二组，全身注射生理盐水或纳洛酮。结果表明，将纳洛酮注入CA3或全身注射对一个和两个线索产生了明显的破坏，但对三个或四个线索的破坏作用最小，这表明纳洛酮注射破坏了CA3功能，并引发了模式完成过程中的缺陷。因此，似乎背侧CA3的基于线索的激活可能是通过图案完成过程的关键触发。基于额外的分析，似乎主要对于物体触摸存在中断，用于一个线索纳洛酮注射到CA3或全身注射，但对时间没有影响（空间背景）。
The goal of the present research was to assess the degree to which a pattern completion process operates in cue-induced relapse to cocaine-seeking behavior. Using a novel cue-preference version of the place preference task, rats were administered cocaine or saline, which resulted in a preference for the cocaine-paired cues. After 21 days of abstinence and prior to the preference test, for one group, PBS or naloxone was injected into the CA3 subregion of the hippocampus and for a second group, saline or naloxone was injected systemically. The results indicated that infusions of naloxone into CA3 or systemic injections produced a marked disruption for one and two cues, but had minimal disruptive effect for three or four cues, suggesting that naloxone injections disrupt CA3 function and trigger a deficit in a pattern completion process. Thus, it appears that cue-based activation of the dorsal CA3 might be a critical trigger via a pattern completion process. Based on additional analyses it appears that there is a disruption primarily for object touches for one cue naloxone injections into the CA3 or systemic injections, but no effect on time (spatial context).