CORRELATION AND PREDICTIVE ACCURACY OF CIRCULATING IMMUNE-COMPLEXES WITH DISEASE-ACTIVITY IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
CORRELATION AND PREDICTIVE ACCURACY OF CIRCULATING IMMUNE-COMPLEXES WITH DISEASE-ACTIVITY IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
复制标题
DOI：
10.1002/art.1780230302
复制
发表时间：
1980-01-01
影响因子：
--
通讯作者：
GLASSOCK, RJ
中科院分区：
文献类型：
--
作者：
ABRASS, CK;NIES, KM;GLASSOCK, RJ
对48例系统性红斑狼疮(SLE)患者系列血清进行补体C3、抗DNA抗体和循环免疫复合物(CIC)检测。CIC的测定采用液体相(FClq)和固相(SClq)Clq结合试验。SCLQ结果的升高与系统性红斑狼疮(P<；0.001)的表现相关，包括活动性肾脏疾病(P<；0.005)、关节炎(P<；0.001)以及促使医生采取行动的疾病活动程度的变化。SCLQ结果的变化在82%的时间内正确地预测了疾病活动性的变化(P<；0.005)。FClq、抗DNA抗体和C3的异常与SLE的疾病活动性变化无关，也不能预测SLE的疾病活动性。SCLQ法测定CIC显然是SLE临床活动性最可靠的实验室指标。
Serial serum samples from 48 patients with systemic lupus erythematosus (SLE) were assayed for C3 [complement component 3], anti-DNA antibody and circulating immune complexes (CIC). CIC were measured by the fluid phase (FClq) and solid phase (SClq) Clq binding assays. Elevations of SClq results were associated with the presence of manifestations of SLE (P < 0.001), including active renal disease (P < 0.005), arthritis (P < 0.001) and changes in degree of disease activity which prompted physician action. A change in the SClq results correctly predicted change in disease activity 82% of the time (P < 0.005). Abnormalities of FClq, anti-DNA antibody and C3 were neither associated with nor predictive of changes in disease activity of SLE. The SClq method of determining CIC is apparently the most reliable laboratory indicator of clinical activity in SLE.