Predominant Role of Plasmacytoid Dendritic Cells in Stimulating Systemic Autoimmunity.
Predominant Role of Plasmacytoid Dendritic Cells in Stimulating Systemic Autoimmunity.
复制标题
浆细胞样树突状细胞在刺激系统性自身免疫中的主要作用。
DOI：
10.3389/fimmu.2015.00526
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发表时间：
2015
影响因子：
7.3
通讯作者：
Cao W
中科院分区：
文献类型：
--
作者：
Huang X;Dorta-Estremera S;Yao Y;Shen N;Cao W
浆细胞样树突状细胞（Plasmacytoid dendritic cells，pDC）是一种主要的I型干扰素（interferon，IFN-1）产生免疫细胞，广泛参与系统性红斑狼疮（systemic lupus erythematosus，SLE）的发病。然而，它们是否在狼疮发病机制中发挥关键作用仍不清楚。最近使用各种遗传和细胞类型特异性消融策略的研究已经证明，pDC在不同实验条件下在自身抗体的发展和狼疮的进展中起关键作用。几项研究的发现强调了pDC在狼疮发展的早期阶段起关键作用的概念。特别地，pDC在体内对B细胞活化和体液自身免疫具有深远的影响。对pDC在狼疮发病机制中的重要作用的这种更深入的理解支持了pDC-IFN-I途径在SLE中的治疗靶向。
Plasmacytoid dendritic cells (pDCs), which are prominent type I interferon (IFN-I)-producing immune cells, have been extensively implicated in systemic lupus erythematosus (SLE). However, whether they participate critically in lupus pathogenesis remains unknown. Recent studies using various genetic and cell type-specific ablation strategies have demonstrated that pDCs play a pivotal role in the development of autoantibodies and the progression of lupus under diverse experimental conditions. The findings of several investigations highlight a notion that pDCs operate critically at the early stage of lupus development. In particular, pDCs have a profound effect on B-cell activation and humoral autoimmunity in vivo. This deeper understanding of the vital role of pDCs in lupus pathogenesis supports the therapeutic targeting of the pDC-IFN-I pathway in SLE.