Association between plasma paraquat level and outcome of paraquat poisoning in 375 paraquat poisoning patients
Association between plasma paraquat level and outcome of paraquat poisoning in 375 paraquat poisoning patients
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DOI：
10.1080/15563650701549403
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发表时间：
2008-01-01
影响因子：
3.3
通讯作者：
Hong, Sae-Yong
中科院分区：
文献类型：
--
作者：
Gil, Hyo-Wook;Kang, Mun-Soo;Hong, Sae-Yong
目标.摄入百草枯中毒往往是致命的。许多研究调查了治疗方式和预测参数，但没有标准的治疗方法。血浆百草枯浓度似乎是一个有效的可预测生存参数。为了实现统一的治疗，包括体外清除和抗氧化治疗，需要根据血浆百草枯水平调查百草枯中毒的结局。方法.这项研究包括了375名百草枯中毒患者，这些患者于2005年1月至2006年12月在韩国顺春香大学天安医院农药中毒研究所通过摄入百草枯后24小时内的血浆百草枯浓度进行诊断。所有患者均按照统一的方案进行治疗，包括体外消除和抗氧化治疗。采用高效液相色谱法测定血浆百草枯浓度。结果百草枯中毒患者的平均年龄为48.42 ± 6.75岁。110例患者（29.3%）存活。存活者血浆百草枯浓度的上限在3小时时为2.64。百草枯血药浓度在3.44以上的患者全部死亡。百草枯致死的最低浓度非常低（5小时为0.12微克/毫升; 12小时为0.02微克/毫升; 24小时为0.01微克/毫升）。结论.我们的数据表明，血浆百草枯浓度是存活者的良好预测因子，但在低血浆百草枯浓度下，不能很好地预测死亡者。
Objectives. Paraquat poisoning by ingestion is often fatal. Many studies have investigated treatment modalities and predictor parameters, but there is no standard treatment. Plasma paraquat concentration seems a valid predictable parameter of survival. In order to achieve uniform treatment, including extracorporeal elimination and antioxidant therapy, the outcome of paraquat poisoning based on plasma paraquat level needs to be investigated. Methods. This study included 375 paraquat poisoning patients who were diagnosed by means of plasma paraquat concentration within 24 hours after ingestion in the Institute of Pesticide Poisoning of Soonchunhyang University Cheonan Hospital, Korea, from January 2005 to December 2006. All patients were treated according to a uniform protocol including extracorporeal elimination and antioxidant therapy. Plasma paraquat concentration was measured by high-performance liquid chromatography. Results. The mean age of the paraquat-intoxicated patients was 48.42 +/- 6.75. One hundred ten patients (29.3%) survived. The upper limit of plasma paraquat concentration in survivors was 2.64 at 3 hour. All patients with plasma paraquat level above 3.44 died. The minimum paraquat level of the deaths was very low (0.12 mu g/ml at 5 hours; 0.02 mu g/ml at 12 hours; 0.01 mu g/ml at 24 hours). Conclusions. Our data showed that plasma paraquat concentration is good predictor of survivors but is not good predictor of non-survivors in the low plasma paraquat level.