Conditional mutator phenotypes in hMSH2-deficient tumor cell lines.
Conditional mutator phenotypes in hMSH2-deficient tumor cell lines.
复制标题
hMSH2 缺陷肿瘤细胞系中的条件突变表型。
DOI：
10.1126/science.277.5331.1523
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Meuth,M
中科院分区：
文献类型：
--
作者：
Richards,B;Zhang,H;Phear,G;Meuth,M
Two human tumor cell lines that are deficient in the mismatch repair protein hMSH2 show little or no increase in mutation rate relative to that of a mismatch repair–proficient cell line when the cells are maintained in culture conditions allowing rapid growth. However, mutations accumulate at a high rate in these cells when they are maintained at high density. Thus the mutator phenotype of some mismatch repair–deficient cell lines is conditional and strongly depends on growth conditions. These observations have implications for tumor development because they suggest that mutations may accumulate in tumor cells when growth is limited.
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影响因子：
11.2
作者：
M. Meyers;Maria Theodosiou;Samir Acharya;E. Odegaard;Teresa Wilson;Janet E. Lewis;Thomas W. Davis;Carmell Wilson Van Patten;Richard Fishel;D. Boothman
通讯作者：
M. Meyers;Maria Theodosiou;Samir Acharya;E. Odegaard;Teresa Wilson;Janet E. Lewis;Thomas W. Davis;Carmell Wilson Van Patten;Richard Fishel;D. Boothman
影响因子：
56.9
作者：
DRUMMOND, JT;LI, GM;MODRICH, P
通讯作者：
MODRICH, P
影响因子：
11.2
作者：
T. Y. Reynolds;S. Rockwell;P. Glazer
通讯作者：
T. Y. Reynolds;S. Rockwell;P. Glazer
影响因子：
4.7
作者：
Glaab, WE;Tindall, KR
通讯作者：
Tindall, KR
结肠癌中 hprt 位点突变率的增加伴随着微卫星不稳定性。
DOI：
--
发表时间：
1995
期刊：
Oncogene.
影响因子：
--
作者：
Eshleman,JR;Lang,EZ;Bowerfind,GK;Parsons,R;Vogelstein,B;Willson,JK;Veigl,ML;Sedwick,WD;Markowitz,SD
通讯作者：
Markowitz,SD