Prediction of Alzheimer's disease pathophysiology based on cortical thickness patterns.
Prediction of Alzheimer's disease pathophysiology based on cortical thickness patterns.
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DOI：
10.1016/j.dadm.2015.11.008
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Na, Duk L
中科院分区：
文献类型：
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作者：
Hwang, Jihye;Kim, Chan Mi;Na, Duk L
简介：最近的研究表明，阿尔茨海默病 (AD) 的病理学亚型代表了独特的萎缩模式和临床特征。我们研究了基于皮质厚度的聚类方法是否可以反映此类发现。 方法：来自阿尔茨海默氏病神经影像计划 2 数据集的总共 77 名 AD 受试者接受了 3-T 磁共振成像、[(18)F]-氟脱氧葡萄糖-正电子发射断层扫描 (PET)、[(18)F]-氟倍他吡 PET 和脑脊液检查 进行了脑脊液（CSF）测试。根据皮质厚度进行聚类后，对这些组之间的不同成像和生物流体生物标志物进行比较。结果：注意到三种皮质变薄模式：内侧颞叶（MT；19.5%）、弥漫性（55.8%）和顶叶显性（P；24.7%）萎缩亚型。 P亚型是最年轻的，代表顶叶和枕叶皮质中更多的葡萄糖代谢减退，并且大多数大脑区域有明显的β-淀粉样蛋白积累。 MT 亚型显示左侧海马体和双侧额叶皮质的葡萄糖代谢低下较多，记忆测试中的表现较差。脑脊液测试结果在各组之间没有差异。讨论：皮质厚度模式可以反映 AD 的病理生理和临床变化。
INTRODUCTION: Recent studies have shown that pathologically defined subtypes of Alzheimer's disease (AD) represent distinctive atrophy patterns and clinical characteristics. We investigated whether a cortical thickness-based clustering method can reflect such findings.METHODS: A total of 77 AD subjects from the Alzheimer's Disease Neuroimaging Initiative 2 data set who underwent 3-T magnetic resonance imaging, [(18)F]-fluorodeoxyglucose-positron emission tomography (PET), [(18)F]-Florbetapir PET, and cerebrospinal fluid (CSF) tests were enrolled. After clustering based on cortical thickness, diverse imaging and biofluid biomarkers were compared between these groups.RESULTS: Three cortical thinning patterns were noted: medial temporal (MT; 19.5%), diffuse (55.8%), and parietal dominant (P; 24.7%) atrophy subtypes. The P subtype was the youngest and represented more glucose hypometabolism in the parietal and occipital cortices and marked amyloid-beta accumulation in most brain regions. The MT subtype revealed more glucose hypometabolism in the left hippocampus and bilateral frontal cortices and less performance in memory tests. CSF test results did not differ between the groups.DISCUSSION: Cortical thickness patterns can reflect pathophysiological and clinical changes in AD.