Mechanisms for Split Localization of Fgf10 Expression in Early Lung Development
Mechanisms for Split Localization of Fgf10 Expression in Early Lung Development
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DOI：
10.1002/dvdy.22108
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发表时间：
2009-11-01
影响因子：
2.5
通讯作者：
Morishita, Yoshihiro
中科院分区：
文献类型：
--
作者：
Hirashima, Tsuyoshi;Iwasa, Yoh;Morishita, Yoshihiro
在早期肺发育中，上皮管（肺芽）侵入被胸膜细胞覆盖的间充质（肺缘），并通过重复使用形态发生过程（“伸长”、“末端分叉”和“侧向出芽”）形成树状网络。“当芽伸长时，Fgf 10表达的峰值在尖端附近的间充质中形成;而当末端分叉和侧向出芽发生时，则形成两个独立的峰值。为了解释Fgf 10表达的空间模式，我们开发了一个数学模型，用于调节Fgf 10表达的几何条件，包括肺芽和肺边界的形状。不同的定位模式Fgf 10的表达可以解释的几何条件。当肺芽尖与肺缘之间的长度较大时，fgf 10的表达呈单峰。当肺段较小时，Fgf 10表达呈双峰型，其位置取决于肺边界的曲率。发展动力学238：28132822，2009年。(C)2009 Wiley-Liss，Inc.
In early lung development, epithelial tubes (lung buds) intrude into mesenchyme covered with pleural cells (lung border), and form tree-like networks, by means of repeated use of morphogenetic processes: "elongation," "terminal bifurcation," and "lateral budding." When a bud is elongating, a peak of Fgf10 expression is formed in the mesenchyme near the tip; whereas when terminal bifurcation and lateral budding occur, two separate peaks are formed instead. To explain the spatial pattern of Fgf10 expression, we developed a mathematical model for the regulation of Fgf10 expression with geometrical conditions including shapes of the lung buds and the lung border. Different localization patterns of Fgf10 expression can be explained by the geometrical conditions. Fgf10 expression has a single peak when a length between the tip of lung bud and the lung border is large. When the length is small, Fgf10 expression has two peaks, whose location depends on the curvature of lung border. Developmental Dynamics 238:28132822, 2009.(C) 2009 Wiley-Liss, Inc.