ANATOMICAL AND PHYSIOLOGICAL OBSERVATIONS ON SUPRASPINAL CONTROL OF BLADDER AND URETHRAL SPHINCTER MUSCLES IN THE CAT
ANATOMICAL AND PHYSIOLOGICAL OBSERVATIONS ON SUPRASPINAL CONTROL OF BLADDER AND URETHRAL SPHINCTER MUSCLES IN THE CAT
复制标题
DOI：
10.1002/cne.902500404
复制
发表时间：
1986-08-22
影响因子：
2.5
通讯作者：
DALM, E
中科院分区：
文献类型：
--
作者：
HOLSTEGE, G;GRIFFITHS, D;DALM, E
在15只猫的脑桥被中注射3h -亮氨酸。在桥脑背外侧被内侧（m区）注射后，在骶骨中间、中间和中间外侧细胞组产生特异性的投射。中间外侧细胞群包含神经节前副交感神经细胞，构成膀胱逼尿肌的运动供应。在脑桥被盖区外侧（l区）注射，在Onuf核中产生标记纤维，其中包含支配骨盆底的运动神经元，包括肛门括约肌和尿道括约肌。骶神经节前副交感神经的l区投射和Onuf核的m区投射非常有限或不存在。对12只猫进行了生理实验。l区电刺激引起盆底肌电图和尿道压力的迅速增加，但对膀胱内压力的影响很小。刺激m区引起盆底肌电图迅速下降，尿道压力随后在延迟2秒后增加膀胱内压力，从而模拟正常排尿。
In 15 cats injections of 3H-leucine were made in the pontine tegmentum. Injections in the medial part of the dorsolateral pontine tegmentum (M-region) resulted in specific projections to the sacral intermediomedial and intermediolateral cell groups. The intermediolateral cell group contains preganglionic parasympathetic neurons that form the motor supply of the detrusor muscle of the bladder. Injections in the lateral part of the pontine tegmental field (L-region) produced labeled fibers in the nucleus of Onuf, which contains motoneurons innervating the pelvic floor including the anal and urethral sphincters. L-region projections to the sacral preganglionic parasympathetic neurons and M-region projections to the nucleus of Onuf were very limited or absent. In 12 cats physiological experiments were performed. Electrical stimulation in the L-region elicited a prompt increase in the pelvic floor EMG and urethral pressure but had little influence on the intravesical pressure. Stimulation in the M-region elicited a prompt decrease in the pelvic floor EMG and urethral pressure followed, after a delay of 2 seconds, by an increase in the intravesical pressure, so simulating normal micturition.