STAPHYLOCOCCAL COAGULASE - MODE OF ACTION AND ANTIGENICITY
STAPHYLOCOCCAL COAGULASE - MODE OF ACTION AND ANTIGENICITY
复制标题
DOI：
10.1099/00221287-6-1-2-95
复制
发表时间：
1952-01-01
期刊：
影响因子：
--
通讯作者：
LORENZ, LL
中科院分区：
文献类型：
--
作者：
DUTHIE, ES;LORENZ, LL
对几株葡萄球菌生产游离凝固酶进行了研究，其中一株菌株“纽曼”被用来生产本工作所用的凝固酶。对凝固酶激活剂的物理性质进行了研究，并与凝血酶原激活剂进行了比较，发现两者有明显的相似之处，主要不同之处在于凝血酶原不能耐受赛兹滤过。在人类血清中发现了凝固酶抗体，在那些慢性葡萄球菌感染的人中抗体水平很高。兔损伤后可产生抗凝血酶抗体。反复服用大剂量药物。司令官。凝固酶激活剂在人、猴、马、猫、猪、禽、兔等动物中含量较高，在牛、羊、狗、豚鼠和小鼠中含量较低。
Several strains of staphylococci were studied for free-coagulase production, and a strain "Newmann" was used to produce the coagulase used in this work. The physical properies of coagulase activator were studied and compared with those of prothrombin: the 2 were found to be markedly similar, differing chiefly in the inability of prothrombin to withstand Seitz filtration. Antibodies to coagulase were found in the sera of humans, being high in those individuals with chronic staphylococcal infections. Antibodies to coagulase could be produced in rabbits by injn. of repeated large doses. The concn. of coagulase activator in plasma was high in humans, monkeys, horses, cats, pigs, fowls, and rabbits, and low in cows, sheep, dogs, guinea-pigs, and mice.