Expression of erbB receptors mRNA in thyroid tissues
Expression of erbB receptors mRNA in thyroid tissues
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DOI：
10.1016/j.bbagen.2004.04.016
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发表时间：
2004-08-04
影响因子：
3
通讯作者：
Nagasaka, A
中科院分区：
文献类型：
--
作者：
Kato, S;Kobayashi, T;Nagasaka, A
ErbB家族成员如表皮生长因子受体1 （erbB1）、erbB2、erbB3和erbB4广泛分布于器官组织中，这些受体被怀疑是肿瘤发生因子。我们使用Genescan检测良性和恶性甲状腺肿瘤或Graves病甲状腺组织中的erbB mRNA。ErbB2与侵袭性癌症相关，被用作该疾病的生物学标志物；Northern blot和逆转录聚合酶链反应（RT-PCR）分析显示，它在Graves病中增加。其他研究表明，在乳头状癌细胞中也有类似的结果；crbB2和erbB3 mRNA表达升高，而erbB4 mRNA表达降低，提示erbB表达畸变可能与肿瘤发生有关。然而，只有erbB2过表达与Graves病有关。这些数据进一步暗示了跨膜型受体在甲状腺肿瘤发生中的作用。(C) 2004 Elsevier B.V.版权所有
ErbB family members, such as epidermal growth factor receptor 1 (erbB1), erbB2, erbB3 and erbB4, are widely distributed in organ tissues, and these receptors are suspected tumorigenesis factors.We measured erbB mRNA in thyroid tissues of benign and malignant thyroid tumors or Graves' disease using Genescan. ErbB2 is associated with aggressive cancers and is used as a biological marker for the disease; Northern blot and reverse transcription-polymerase chain reaction (RT-PCR) analyses have shown it to be increased in Graves' disease. Additional studies indicated a similar result in papillary carcinoma cells; mRNAs of crbB2 and erbB3 were increased but erbB4 mRNA was decreased, suggesting distorted erbB expression may be associated with tumorigenesis. However, only erbB2 overexpression is associated with Graves' disease. These data further implicate transmembrane-type receptors in tumorigenesis in the thyroid. (C) 2004 Elsevier B.V. All rights reserved.