Muscular changes in osteoarthritis of the hip and knee.
Muscular changes in osteoarthritis of the hip and knee.
复制标题
髋部和膝部骨关节炎的肌肉变化。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
K. Suzuki
中科院分区：
文献类型：
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作者：
T. Nakamura;K. Suzuki
对退行性骨关节炎患者的肌肉异常进行了组织学和组织化学检查。对26例膝骨关节炎患者股外侧肌活检和21例髋骨关节炎患者臀中肌标本进行DPNH-四唑还原酶和肌球蛋白ATP酶染色，pH值分别为10.4和4.6。所有标本均在手术时获得。患者均为女性，年龄40 ~ 74岁。对照标本来自16名骨折的女性，没有关节炎。2型纤维萎缩和内部紊乱的纤维被发现在两个骨关节炎和对照肌肉，但更常见于股外侧肌的膝关节骨关节炎患者。膝关节骨性关节炎患者股外侧肌纤维类型的异常镶嵌模式，如纤维类型分组和2型纤维分组萎缩，常见于膝关节骨性关节炎患者股外侧肌（73.1%），而对照组较少见（6.3%）。然而，在骨关节炎患者或对照组的臀中肌中未发现异常镶嵌图案。膝关节骨关节炎股外侧肌中纤维类型镶嵌模式的异常变化可能提示相关的运动神经元功能障碍;髋关节骨关节炎患者的臀中肌标本中未观察到异常，可能涉及神经因素的不同背景。
Muscular abnormalities in the patients with degenerative osteoarthritis were examined histologically and histochemically. Enzyme stainings for DPNH-tetrazolium reductase and myosin ATP-ase at pH 10.4 and 4.6 were performed on 26 vastus lateralis biopsies from the patients with osteoarthritis of the knee and 21 gluteus medius specimens from those with osteoarthritis of the hip. All specimens were obtained at surgery. The patients were all female with their ages ranging from 40 to 74 years. Control specimens were obtained from 16 fractured females with absence of arthritis. Type 2 fiber atrophy and internal derangement of fibers were found in both osteoarthritic and control muscles, but were more frequently seen in the vastus lateralis of the patients with osteoarthritis of the knee. Abnormal mosaic patterns of fiber types, such as fiber type grouping and grouped atrophy of type 2 fibers, were frequently found in the vastus lateralis of the patients with osteoarthritis of the knee (73.1%), and less frequently in that of controls (6.3%). However, abnormal mosaic patterns were not found in the gluteus medius obtained from either osteoarthritic patients or control subjects. Abnormal changes in mosaic pattern of fiber types in the vastus lateralis of osteoarthritis of the knee may suggest associated motor neuron dysfunction; the abnormality was not observed in the gluteus medius specimens of the patients with osteoarthritis of the hip, for which a different background in neurological factors may be involved.