Examining sleep, fatigue, and daytime sleepiness in pediatric multiple sclerosis patients
Examining sleep, fatigue, and daytime sleepiness in pediatric multiple sclerosis patients
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检查儿童多发性硬化症患者的睡眠、疲劳和白天嗜睡
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
K. Bashir
中科院分区：
文献类型：
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作者：
A. Zafar;J. Ness;Sarah Dowdy;K. Avis;K. Bashir
背景：大约2-5%的多发性硬化症（MS）患者在18岁之前出现首次症状。睡眠障碍经常发生在MS中。儿童MS中睡眠问题的患病率及其对疲劳和日间嗜睡的影响尚不清楚。目的：确定与年龄、性别和种族匹配的对照组相比，儿童MS患者是否有更多的睡眠障碍、疲劳和日间嗜睡。研究方法：对患者和年龄、性别和种族匹配的对照组进行调查，通过改良的埃普沃思嗜睡量表量化白天嗜睡，通过青少年睡眠觉醒和卫生量表分别量化睡眠质量和卫生，并使用PediatricQL多维疲劳量表量化疲劳。结果如下：儿童MS患者（n = 30）和年龄、性别和种族匹配的对照组（n = 52）具有相似的疲劳水平;然而，与先前发表的历史对照组相比，两组报告的所有维度的疲劳均更差（p < 0.05）。与对照组相比，儿童MS患者的睡眠质量也相似，但在“睡眠稳定性”维度上报告了更好的睡眠卫生（p < 0.05）。此外，儿童MS患者的日间嗜睡少于匹配的对照组（p < 0.05）。结论：虽然MS患者报告了类似的疲劳程度，但他们有更好的睡眠卫生，这可能是白天过度嗜睡减少的原因。此外，与历史对照品相比，MS和对照品报告的疲劳程度更高。因此，在使用已发表的对照数据时必须谨慎，特别是在匹配不当时。
Background: About 2–5% of patients with multiple sclerosis (MS) experience their first symptoms before age 18. Sleep disorders occur frequently in MS. The prevalence of sleep problems and their impact on fatigue and daytime sleepiness in pediatric MS is unknown. Objective: To determine whether pediatric MS patients have more sleep disturbances, fatigue, and daytime sleepiness compared with an age-, sex-, and race-matched control group. Methods: Patients and age-, sex-, and race-matched controls were surveyed to quantify daytime sleepiness via the modified Epworth Sleepiness Scale, sleep quality and hygiene through the Adolescent Sleep Wake and Hygiene Scale, respectively, and fatigue using the PediatricQL Multidimensional Fatigue Scale. Results: Pediatric MS patients (n = 30) and age-, sex-, and race-matched controls (n = 52) had similar levels of fatigue; however, when compared with previously published historical controls, both groups reported worse fatigue across all dimensions (p < 0.05). Pediatric MS patients also had similar sleep quality compared with the matched controls, but reported better sleep hygiene on the ‘sleep stability’ dimension (p < 0.05). In addition, pediatric MS patients had less daytime sleepiness than the matched controls (p < 0.05). Conclusion: Although patients with MS reported similar levels of fatigue, they have better sleep hygiene, which could possibly account for the decreased amount of excessive daytime sleepiness. Also, when compared with historical controls, the MS and control samples reported more fatigue. Thus, caution must be taken when using published control data, especially when not properly matched.