Application of the chiral bis(phosphine) monoxide ligand to catalytic enantioselective addition of dialkylzinc reagents to β-nitroalkenes
Application of the chiral bis(phosphine) monoxide ligand to catalytic enantioselective addition of dialkylzinc reagents to β-nitroalkenes
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DOI：
10.1021/ol062792t
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发表时间：
2007-01-04
期刊：
影响因子：
5.2
通讯作者：
Charette, Andre B.
中科院分区：
文献类型：
--
作者：
Cote, Alexandre;Lindsay, Vincent N. G.;Charette, Andre B.
在铜催化的对映选择性二烷基锌试剂加成反应中，Me-DuPHOS是一种非常有效的配体，可以获得手性硝基烷烃。该工艺的主要优点是产率高，底物范围广，对映选择性高。非手性假配体作为添加剂的作用也有文献记载。
Me-DuPHOS monoxide is shown to be a very effective ligand in the enantioselective copper-catalyzed addition of dialkylzinc reagents to beta-nitroalkenes providing access to chiral nitroalkanes. The major advantages of this process are high yields, broad and complementary substrate scope, and high enantioselectivities. The effect of achiral dummy ligands as an additive has also been documented.