Noninvasive measurement of three-dimensional myocardial deformation with tagged magnetic resonance imaging during graded local ischemia
Noninvasive measurement of three-dimensional myocardial deformation with tagged magnetic resonance imaging during graded local ischemia
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DOI：
10.3109/10976649909088333
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发表时间：
1999-01-01
影响因子：
6.4
通讯作者：
Zerhouni, EA
中科院分区：
文献类型：
--
作者：
Moore, CC;McVeigh, ER;Zerhouni, EA
本研究旨在探讨犬左心室三维（3D）变形模式与局部灌注分级减少之间的关系。使用临床扫描仪中的磁共振（MR）组织标记来确定整个左心室的收缩期3D变形，时间分辨率为32毫秒。在正常和左前降支冠状动脉血流水平降低的情况下对6只犬进行了研究，共计14项研究。通过将3D位移场与来自三组正交标签的标签位移数据拟合并取空间导数来计算变形。一个新的指数的3D径向力学功能，计算出的3D应变张量分量和组织不可压缩性约束，有一个更高的相关性（R = 0.94）灌注（彩色微球）比任何的3D拉格朗日有限应变传感器组件或壁增厚。作为基线灌注分数的函数，通过低于正常灌注的线性关系，斜率为0.46 +/- 0.05，截距为-0.156 +/- 0.026，纵向应变首先随着灌注减少而丢失（48%），其次是环周向（40%），最后是径向功能（35%）。应变方法检测到灌注下降小至20%，和早期矛盾的应变瞬态持续100毫秒，只与缺血。可以通过MR组织标记无创地测量整个左心室的3D应变变化。磁共振成像衍生的SAAIN指数，独特的3D分析，最敏感的相关性与犬左心室的局部灌注。
The purpose of this study was to investigate the relationship between three-dimensional (3D) deformation patterns in the canine left ventricle and localized graded reductions in perfusion. Magnetic resonance (MR) tissue tagging in a clinical scanner was used to determine systolic 3D deformation throughout the left ventricle with 32-msec time resolution. Six dogs were studied at normal and reduced left anterior descending coronary artery flow levels, for a total of 14 studies. Deformation was calculated by fitting a 3D displacement field to tag displacement data from three orthogonal sets of tags and taking spatial derivatives. A novel index of 3D radial mechanical function, calculated from the 3D strain tensor components and the tissue incompressibility constraint, had a higher correlation (R = 0.94) with perfusion (colored microspheres) than any of the 3D Lagrangian finite strain censor components or wall thickening. As a function of the fraction of baseline perfusion, it was well Jit by a lineal relationship for subnormal perfusion with a slope of 0.46 +/- 0.05 and an intercept of -0.156 +/- 0.026 Longitudinal strain was lost first with decreasing perfusion (48%), followed by cir circumferential (40%) and finally radial function (35%). The strain method detected perfusion drops as small as 20%, and early paradoxical strain transients lasting 100 msec were seen only with ischemia. 3D strain changes can be noninvasively measured throughout the left ventricle with MR tissue tagging. MR imaging-derived sa ain indices, unique to 3D analysis, correlate most sensitively with regional perfusion in the canine left ventricle.