The usefulness of cerebrospinal fluid tests for neurosyphilis.
The usefulness of cerebrospinal fluid tests for neurosyphilis.
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脑脊液测试对神经梅毒的有用性。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
J. Joubert
中科院分区：
文献类型：
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作者：
H. Russouw;M. Roberts;R. Emsley;J. Joubert
为了确定脑脊液(CSF)梅毒检测在大型学术医院的有效性，对644名患者的临床和实验室数据进行了分析，这些患者在12个月内被要求进行梅毒检测。198例(31%)因液体不足而未能进行梅毒螺旋体血凝试验(TPHA)筛查。其余38名患者被诊断为患有活动性神经梅毒。对22份TPHA阳性、梅毒螺旋体抗体吸收(FTA-Abs)试验阳性、脑脊液(CSF)性病研究实验室(VDRL)试验阴性的患者的档案进行检查后发现，表明疾病活动性的其他脑脊液指标(脑脊液蛋白、细胞或免疫球蛋白指数)没有得到最佳利用。在这些患者中，有10例(45%)在脑脊液生化分析异常或不完全的情况下仍未被诊断为神经梅毒，这表明如果将脑脊液VDRL作为疾病活动性的唯一标志，可能会漏掉一些神经梅毒病例。
To determine the usefulness of cerebrospinal fluid (CSF) tests for syphilis at a large academic hospital, clinical and laboratory data on 644 patients in whom such testing was requested over a 12-month period were analysed. In 198 cases (31%) the Treponema pallidum haemagglutination (TPHA) screening test could not be performed because of insufficient fluid. Thirty-eight of the remaining patients were diagnosed as having active neurosyphilis. Examination of 22 files of patients who had a positive TPHA and fluorescent treponemal antibody absorption (FTA-Abs) test together with a negative CSF Venereal Disease Research Laboratory (VDRL) test revealed that other CSF measures indicating disease activity (CSF protein, cells or IgG index) were not utilised optimally. In 10 (45%) of these patients neurosyphilis was not diagnosed despite either abnormal or incomplete CSF biochemical analysis, indicating that if the CSF VDRL is used as the sole marker for disease activity, some cases of neurosyphilis are likely to be missed.