Decreased vascularization and cell proliferation in placentas of intrauterine growth-restricted fetuses with abnormal umbilical artery flow velocity waveforms
Decreased vascularization and cell proliferation in placentas of intrauterine growth-restricted fetuses with abnormal umbilical artery flow velocity waveforms
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DOI：
10.1067/mob.2002.125243
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发表时间：
2002-09-01
影响因子：
9.8
通讯作者：
Aplin, JD
中科院分区：
文献类型：
--
作者：
Chen, CP;Bajoria, R;Aplin, JD
目的：本研究的目的是比较重度宫内胎儿生长受限伴脐动脉血流速度波形异常与正常妊娠胎盘的形态学特征。免疫组化法检测细胞增殖、血管密度、和9例年龄匹配的子宫内生长的间质细胞的β-平滑肌肌动蛋白表达，结果：宫内生长受限组胎盘滋养层细胞和间质细胞中MIB 1阳性细胞核均减少，提示周期细胞减少。此外，血管密度大大降低，观察到，沿着与较高水平的α-平滑肌肌动蛋白在基质cells.CONCLUSION：宫内生长受限的胎盘显示减少细胞增殖的滋养层和基质细胞的车厢。外周绒毛血管化高度减少。
OBJECTIVE: The purpose of this study was to compare the morphologic features of placentas in severe intrauterine fetal growth restriction with abnormal umbilical artery blood flow velocity waveforms and normal gestation.STUDY DESIGN: Immunohistochemical methods were used to evaluate cell proliferation, vascular density, and (x-smooth muscle actin expression by stromal cells in a group of 9 age-matched intrauterine growth-restricted and control placentas at 25 to 41 weeks of gestation.RESULTS: Fewer MIB1-positive nuclei were observed in both trophoblast and stromal cell populations in intrauterine growth restriction, which indicates fewer cells in cycle. Furthermore, a greatly reduced vascular density was observed, along with higher levels of alpha-smooth muscle actin expression in stromal cells.CONCLUSION: Intrauterine growth-restricted placentas show reduced cell proliferation in both trophoblast and stromal cell compartments. Peripheral villous vascularization is highly reduced.