Xanthene‐Based Nitric Oxide‐Responsive Nanosensor for Photoacoustic Imaging in the SWIR Window
Xanthene‐Based Nitric Oxide‐Responsive Nanosensor for Photoacoustic Imaging in the SWIR Window
复制标题
基于氮氧化物的呫吨响应型纳米传感器，用于短波红外窗口中的光声成像
DOI：
10.1002/anie.202214855
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Scott, Colleen N.
中科院分区：
文献类型：
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作者：
Rathnamalala, Chathuranga S. L.;Hernandez, Selena;Lucero, Melissa Y.;Swartchick, Chelsea B.;Kalam Shaik, Abdul;Hammer, Nathan I.;East, Amanda K.;Gwaltney, Steven R.;Chan, Jefferson;Scott, Colleen N.
短波红外（SWIR）染料的特点是它们能够吸收900到1400 nm的光，由于最小的光散射和内源性色素的干扰，它是深层组织成像的理想选择。获得这种分子的一种方法是调整已知近红外染料的光物理性质。在此，我们报道了一系列基于二氮杂平给体偶联噻吩（SCR‐1）、噻吩（SCR‐2）或噻吩（SCR‐3）的易于获取的（三步）SWIR杂蒽染料的开发。我们利用scr‐1在体内研究中聚集时发生色移的事实，通过开发一氧化氮的比例纳米颗粒（rNP‐NO），我们利用该纳米颗粒通过深层组织SWIR光声（PA）成像成功地可视化了药物诱导肝损伤模型中一氧化氮的病理水平。我们的工作证明了该染料系列可以很容易地用作成像研究纳米传感器设计的组件。
Shortwave infrared (SWIR) dyes are characterized by their ability to absorb light from 900 to 1400 nm, which is ideal for deep tissue imaging owing to minimized light scattering and interference from endogenous pigments. An approach to access such molecules is to tune the photophysical properties of known near‐infrared dyes. Herein, we report the development of a series of easily accessible (three steps) SWIR xanthene dyes based on a dibenzazepine donor conjugated to thiophene (SCR‐1), thienothiophene (SCR‐2), or bithiophene (SCR‐3). We leverage the fact thatSCR‐1undergoes a bathochromic shift when aggregated for in vivo studies by developing a ratiometric nanoparticle for NO (rNP‐NO), which we employed to successfully visualize pathological levels of nitric oxide in a drug‐induced liver injury model via deep tissue SWIR photoacoustic (PA) imaging. Our work demonstrates how easily this dye series can be utilized as a component in nanosensor designs for imaging studies.