Immunologic reconstitution in the acquired immunodeficiency syndrome.
Immunologic reconstitution in the acquired immunodeficiency syndrome.
复制标题
获得性免疫缺陷综合征的免疫重建。
DOI：
--
复制
发表时间：
1985
影响因子：
39.2
通讯作者：
A. Fauci
中科院分区：
文献类型：
--
作者：
H. Lane;A. Fauci
虽然对获得性免疫缺陷综合征(AIDS)患者中发生的许多感染和肿瘤都有有效的治疗方法，但对潜在的免疫缺陷没有治疗方法。用于治疗这种免疫缺陷的三种方法包括通过淋巴细胞转移、骨髓移植和胸腺移植进行全面免疫替代；使用生物反应调节剂增强免疫，如伽马干扰素、白细胞介素2和一些药物；以及抗逆转录病毒治疗。由于病原性病毒的持久性，除非针对该病毒制定有效的策略，否则免疫替代和增强都可能无效。目前正在进行临床试验的体外抗病毒药物包括苏拉明、杂多阴离子-23(HPA-23)、利巴韦林和α干扰素。Foscarnet和单抗还没有进入美国的临床试验。现在判断是否有任何抗病毒药物将被证明对艾滋病患者的治疗有价值还为时过早。
Although effective therapies are available for many of the infections and tumors that occur in patients with the acquired immunodeficiency syndrome (AIDS), no therapy exists for the underlying immunodeficiency. Three approaches used to treat this immunodeficiency have included wholescale immune replacement through lymphocyte transfers, bone marrow transplantation, and thymic implantation; immunologic enhancement with biologic-response modifiers, such as gamma interferon, interleukin-2, and some drugs; and antiretroviral therapy. Because of the persistence of the etiologic virus, both immune replacement and enhancement will probably be ineffective unless effective strategies are developed against the virus. Agents that have shown antiviral activity in vitro which are currently in clinical trials include suramin, heteropolyanion-23 (HPA-23), ribavirin, and alpha interferon. Foscarnet and monoclonal antibodies have yet to enter clinical trials in the United States. It is still too early to tell if any of the antiviral agents will prove of value in the management of patients with AIDS.
DOI：
10.1016/0002-9343(82)90174-7
发表时间：
1982
期刊：
The American journal of medicine
影响因子：
--
作者：
Stahl,RE;Friedman-Kien,A;Dubin,R;Marmor,M;Zolla-Pazner,S
通讯作者：
Zolla-Pazner,S
同性恋男性的获得性免疫功能障碍：免疫学特征。
DOI：
10.1016/0090-1229(83)90084-3
发表时间：
1983
期刊：
Clinical immunology and immunopathology
影响因子：
--
作者：
Ammann,AJ;Abrams,D;Conant,M;Chudwin,D;Cowan,M;Volberding,P;Lewis,B;Casavant,C
通讯作者：
Casavant,C
患有免疫缺陷和卡波西肉瘤的同性恋男性的免疫学研究。
DOI：
10.1016/0090-1229(83)90083-1
发表时间：
1983
期刊：
Clinical immunology and immunopathology
影响因子：
--
作者：
Schroff,RW;Gottlieb,MS;Prince,HE;Chai,LL;Fahey,JL
通讯作者：
Fahey,JL