Salivary and serum adiponectin and C-reactive protein levels in acute myocardial infarction related to body mass index and oral health.
Salivary and serum adiponectin and C-reactive protein levels in acute myocardial infarction related to body mass index and oral health.
复制标题
DOI：
10.1111/jre.12406
复制
发表时间：
2017-06
影响因子：
3.5
通讯作者：
Miller CS
中科院分区：
文献类型：
--
作者：
Ebersole JL;Kryscio RJ;Campbell C;Kinane DF;McDevitt J;Christodoulides N;Floriano PN;Miller CS
脂联素是由脂肪细胞产生的，被认为是一种抗炎分子。相比之下，C反应蛋白已被确定为全身炎症的标志，并被用作心血管疾病的风险标志。令人感兴趣的是这两个生物标志物与口腔健康和心血管风险的关系。本研究检测了48小时内患者血清和未受刺激的全唾液中的这两种分子。将急性心肌梗死(AMI)患者与对照组进行比较。我们假设心脏病发作引起的这些生物分子的不同反应将同时受到个体的BMI和口腔健康特征的影响。急性心肌梗死患者血清脂联素水平明显降低。两组血清脂联素和急性心肌梗死患者唾液脂联素均随BMI增加而降低。急性心肌梗死患者口腔健康状况明显恶化，而对照组患者口腔健康状况较好时，血清和唾液脂联素水平均升高。血清C反应蛋白水平在急性心肌梗死患者中升高，与口腔健康无关，S-T波抬高型心肌梗死患者血清和唾液中C反应蛋白水平均显著升高。这些初步数据提供了将肥胖和口腔健康与唾液和血清分析物水平联系起来的证据，这些水平与心脏事件有关。心血管(CVD)风险和牙周病之间的关系已经被描述。此外，各种全身性炎症生物标志物似乎同时反映了心血管疾病的风险和牙周炎的程度/严重程度。我们的发现表明，口腔健康和肥胖有助于改变唾液和血清中与心脏事件相关的分析物的水平。血清和/或唾液生物标记物可能有助于评估心血管疾病风险，这需要了解个人的口腔健康将如何影响这些生物措施的有效性。
Adiponectin is produced by adipose cells and is considered an anti-inflammatory molecule. In contrast, C-reactive protein has been identified as a hallmark of systemic inflammation and used as a risk marker of cardiovascular disease. Of interest was the relationship of these two biomarkers to oral health and cardiovascular risk. This investigation examined these two molecules in serum and unstimulated whole saliva of patients within 48 hrs. of an acute myocardial infarction (AMI) compared to control subjects. We hypothesized a differential response in these biomolecules resulting from the heart attack that would be affected by both the BMI and oral health characteristics of the individuals. Significantly lower adiponectin levels were observed in the serum of the AMI patients. Serum adiponectin in both groups and salivary adiponectin in AMI patients decreased with increasing BMI. Oral health was significantly worse in the AMI patients, and both serum and salivary adiponectin were elevated with better oral health in control subjects. Serum CRP levels were increased in the AMI patients regardless of their oral health, and both serum and salivary CRP were significantly elevated in S-T wave elevated MI patients (STEMI). These initial data provide evidence relating obesity and oral health to salivary and serum analyte levels that occur in association with cardiac events. Relationships have been described between cardiovascular (CVD) risk and periodontal disease. Additionally, various systemic inflammatory biomarkers appear to reflect both the CVD risk and the extent/severity of periodontitis. Our findings indicated that oral health and obesity contribute to altering levels of these salivary and serum analytes in association with cardiac events. The potential that serum and/or salivary biomarkers could aid in evaluating CVD risk requires knowledge regarding how the oral health of the individual would impact the effectiveness of these biological measures.