The effect of profound dehydration on electrical impedance of mouseskeletal muscle.
The effect of profound dehydration on electrical impedance of mouseskeletal muscle.
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DOI：
10.1109/embc.2014.6943641
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Rutkove SB
中科院分区：
文献类型：
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作者：
Jia Li;Sanchez B;Rutkove SB
为了确定在严重脱水的情况下电阻抗肌电描记 (EIM) 技术是否仍可安全地用于监测肌肉，我们测量了 n=8 只野生型小鼠在 48 小时禁水期间在 1 kHz - 1 MHz（37 个频率）下的电阻抗，并与 n=8 只随意饮水的小鼠的结果进行了比较。根据科尔阻抗模型中 R0 (8% p=0.59) 参数的相对变化，与体重和身体失水量的相对变化相比，肌肉细胞外液没有显着变化（分别为 19.6% p<0.0001 和 26.1% p<0.0001）。 50 kHz 时的相位变化可以忽略不计（1% p=0.88），这证实了肌纤维的结构完整性和活力在这段时间内保持完好。因此，即使在严重脱水期间，EIM 仍可用于确定肌肉状态。
To determine if electrical impedance myography (EIM) technique can still be used safely to monitor muscle in cases of severe dehydration, we measured the electrical impedance at 1 kHz - 1 MHz (37 frequencies) of n=8 wild type mice during 48 h of fluid deprivation and compared to the results of n=8 mice that were provided with water ad libitum. Based on the relative change in the R0 (8% p=0.59) parameter from the Cole impedance model, there is a non-significant change in regard to the muscle extracellular fluid when compared to the relative change of body weight and body water loss (19.6% p<0.0001 and 26.1% p<0.0001 respectively). The negligible changes of the phase at 50 kHz (1% p=0.88) confirm both the muscle fibers structural integrity and viability remained intact for that period of time. Accordingly, EIM can still be used to determine the status of muscle even during profound dehydration.