Medicine - Race and reification in science
Medicine - Race and reification in science
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DOI：
10.1126/science.1110303
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发表时间：
2005-02-18
期刊：
影响因子：
56.9
通讯作者：
Duster, T
中科院分区：
文献类型：
--
作者：
Duster, T
1051的术语，即使有很少的证据表明，他们代表了一个地理定位，生殖隔离组。这些样本往往被巧妙地描绘成代表种族分类的人群。在一个群体中发现某些等位基因的频率高于另一个群体，这是现代技术的必然结果，即使是在两个随机选择的群体中。当这些人群的边界与种族的社会定义相吻合时，需要更好地在以下之间导航：（i）承认种族是社会中的一种分层做法，这可能导致不同现代人群中等位基因的频率不同，但也可能导致获得健康相关资源的不同，（ii）将种族具体化为具有遗传上足够独特的特征，即具有“独特的基因途径”，这被用来解释种族分类人群之间的健康差异。那么它就很容易滑向“黑色”或“白色”疾病的误解。通过接受储存样本的预制种族名称，然后报告这些类别之间SNP差异的模式，错位的遗传具体性几乎是不可避免的。
1051 of the term, even when there is little evidence that they represent a geographically localized, reproductively isolated group. These samples are often subtly portrayed as representing racially categorized populations. Finding a higher frequency of some alleles in one population versus another is a guaranteed outcome of modern technology, even for two randomly chosen populations. When the boundaries of those populations coincide with the social definition of race, a delicate tightrope needs to be better navigated between:(i) acknowledging race as a stratifying practice in societies that can lead to different frequencies of alleles in different modern populations but also to different access to health-related resources, and (ii) reifying race as having genetically sufficiently distinctive features, ie, with “distinctive gene pathways,” which are used to explain health disparities between racially categorized populations.If we fall into the trap of accepting the categories of stored data sets, then it can be an easy slide down the slope to the misconceptions of “black” or “white” diseases. By accepting the prefabricated racial designations of stored samples and then reporting patterns of differences in SNPs between those categories, misplaced genetic concreteness is nearly inevitable.