Evidence for a significant role of CD4+ T cells in adoptive immunity to Listeria monocytogenes in the liver.
Evidence for a significant role of CD4+ T cells in adoptive immunity to Listeria monocytogenes in the liver.
复制标题
CD4 T 细胞在肝脏中单核细胞增生李斯特菌过继免疫中发挥重要作用的证据。
作者：
A. Rakhmilevich
虽然CD8+ T细胞在脾脏中过继免疫小鼠对抗单核细胞增生李斯特菌的能力已经得到很好的建立，但不同T细胞亚群在肝脏（李斯特菌感染的主要靶点）中的抗菌保护作用仍然不清楚。因此，分选的CD4+和CD8+ T细胞过继免疫小鼠抗L.研究了肝脏中的单核细胞增多症感染。结果显示，来自第7天李斯特菌免疫小鼠的阳性分选的CD4+ T细胞与分选的CD8+细胞在肝脏中转移显著的抗李斯特菌保护方面一样有效。当通过抗体诱导的补体介导的体外耗竭阴性选择的CD4+和CD8+ T细胞用于过继转移时，获得了类似的结果。然而，CD8+ T细胞比CD4+ T细胞更有效地在脾脏中转移保护。综上所述，结果表明，CD4+ T细胞至少与CD8+ T细胞一样具有针对L.在肝脏中的单核细胞增多症感染，从而反驳了CD4+ T细胞在过继性免疫中对阿尔茨海默病的重要性有限的观点。
Although the ability of CD8+ T cells to adoptively immunize mice against Listeria monocytogenes in the spleen is well established, the role of different T-cell subsets in anti-bacterial protection in the liver, a major target of Listeria infection, remains unclear. Therefore, the ability of sorted CD4+ and CD8+ T cells to adoptively immunize mice against a L. monocytogenes infection in the liver was studied. The results show that positively sorted CD4+ T cells from day 7 Listeria-immune mice were as effective as sorted CD8+ cells in transferring significant anti-Listeria protection in the liver. Similar findings were obtained when CD4+ and CD8+ T cells, negatively selected by antibody-induced complement-mediated depletion in vitro, were used for adoptive transfer. CD8+ T cells, however, were more efficient than CD4+ T cells in transferring protection in the spleen. Taken together, the results show that CD4+ T cells are at least as protective as CD8+ T cells against a L. monocytogenes infection in the liver, thereby arguing against the view that CD4+ T cells are of limited importance in adoptive immunity against listeriosis.