Prophylaxis of experimental HTLV-I infection in cynomolgus monkeys by passive immunization
Prophylaxis of experimental HTLV-I infection in cynomolgus monkeys by passive immunization
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DOI：
10.1016/s0264-410x(97)00055-8
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发表时间：
1997-08-01
期刊：
影响因子：
5.5
通讯作者：
Yoshikawa, Y
中科院分区：
文献类型：
--
作者：
Akari, H;Suzuki, T;Yoshikawa, Y
作为临床前研究，在食蟹猴（Macaca fascicularis）中检查了纯化人免疫球蛋白抗人T细胞白血病病毒I型（HTLV-I）（命名为ATLIG）对HTLV-I感染的保护作用。在攻击HTLV-I之前24小时被动免疫ATLIG保护猴免受HTLV-I感染。结果表明，ATLIG的被动免疫可以提供针对人类HTLV-I感染的安全和充分的保护。(C)1997年爱思唯尔科学有限公司
The protective effect of purified human immunoglobulin against human T-cell leukaemia virus type I (HTLV-I), designated ATLIG on HTLV-I infection was examined in cynomolgus monkeys (Macaca fascicularis) as a preclinical study. Passive immunization of ATLIG 24 h before challenging HTLV-I protected the monkeys from HTLV-I infection. The result suggests that passive immunization of ATLIG could provide safe and sufficient protection against HTLV-I infection in humans. (C) 1997 Elsevier Science Ltd.