Comparison of coronary atherosclerotic volume in patients with glomerular filtration rates ≤60 versus >60 ml/min/1.73 m2:: A meta-analysis of intravascular ultrasound studies
Comparison of coronary atherosclerotic volume in patients with glomerular filtration rates ≤60 versus >60 ml/min/1.73 m2:: A meta-analysis of intravascular ultrasound studies
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DOI：
10.1016/j.amjcard.2006.10.038
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发表时间：
2007-03-15
影响因子：
2.8
通讯作者：
Nissen, Steven E.
中科院分区：
文献类型：
--
作者：
Nicholls, Stephen J.;Tuzcu, E. Murat;Nissen, Steven E.
研究人员对 989 名冠状动脉疾病受试者的肾小球滤过率 (GFR) < 60 ml/min/1.73 m(2) 与冠状动脉粥样硬化的程度和进展之间的关系进行了研究。尽管年龄较大，更有可能是女性，并且有高血压、糖尿病和搭桥手术史，但低 GFR 受试者的总动脉粥样硬化体积和动脉粥样硬化体积百分比与 GFR > 60 ml/kg/min 的受试者没有差异。同样，GFR 低于和高于 60 ml/min/1.73 m 2 的患者的动脉粥样硬化斑块总体积和动脉粥样硬化斑块体积百分比进展率在高频率使用已建立的预防性治疗后没有差异。总之，研究结果表明，肾功能受损患者临床事件发生率的增加可能是由动脉粥样硬化负担以外的因素造成的。 (c) 2007 Elsevier Inc. 保留所有权利。
The relation between glomerular filtration rate (GFR) < 60 ml/min/1.73 m(2) and the extent and progression of coronary atherosclerosis in 989 subjects with coronary artery disease was investigated. Despite being older, more likely to be women, and having a history of hypertension, diabetes, and bypass surgery, total atheroma volume and percent atheroma volume in subjects with a low GFR did not differ from subjects with a GFR > 60 ml/kg/min. Similarly, there was no difference in progression rates of total atheroma volume and percent atheroma volume in patients with GFRs lower and higher than 60 ml/min/1.73 m 2 in response to a high rate of use of established preventive therapies. In conclusion, findings suggest that the increased incidence of clinical events in patients with impaired renal function may result from factors other than atherosclerotic burden. (c) 2007 Elsevier Inc. All rights reserved.