The association between birthweight and longevity in the rat is complex and modulated by maternal protein intake during fetal life
The association between birthweight and longevity in the rat is complex and modulated by maternal protein intake during fetal life
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DOI：
10.1016/j.febslet.2006.06.062
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发表时间：
2006-07-24
期刊：
影响因子：
3.5
通讯作者：
Sculley, Dean V.
中科院分区：
文献类型：
--
作者：
Langley-Evans, Simon C.;Sculley, Dean V.
在大鼠妊娠期，母体蛋白质限制已被认为通过诱导胎儿生长迟缓，随后是出生后追赶生长，从而缩短所产生后代的寿命。我们测试了这一假设，即男性和女性的寿命都可以通过在胎儿发育的特定阶段暴露于营养不良来编程。在整个妊娠期蛋白质限制显着减少寿命的男性和女性。低出生体重增加寿命，而出生后快速增长有不利影响。没有证据表明营养不良通过主要器官的氧化过程来规划寿命。胎儿编程是老化过程的一个重要因素。(c)2006年欧洲生物化学学会联合会。Elsevier B.V.出版，保留所有权利。
Maternal protein restriction in rat pregnancy has been suggested to reduce lifespan of the resulting offspring by inducing fetal growth retardation, followed by postnatal catch-up growth. We tested the hypothesis that lifespan could be programmed in both males and females by exposure to undernutrition at specific stages of fetal development. Protein restriction throughout gestation significantly reduced lifespan in both males and females. Low birthweight increased longevity, whilst rapid postnatal growth had a detrimental effect. There was no evidence that undernutrition programmed lifespan through oxidative processes in the major organs. Fetal programming is an important contributor to the ageing process. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.