Clinical efficacy of chloroquine versus artemether-lumefantrine for Plasmodium vivax treatment in Thailand
Clinical efficacy of chloroquine versus artemether-lumefantrine for Plasmodium vivax treatment in Thailand
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DOI：
10.3347/kjp.2007.45.2.111
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发表时间：
2007-06-01
影响因子：
--
通讯作者：
Looareesuwan, Sornchai
中科院分区：
文献类型：
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作者：
Krudsood, Srivicha;Tangpukdee, Noppadon;Looareesuwan, Sornchai
氯喹仍然是泰国治疗间日疟的首选药物。恶性疟和间日疟的混合感染在东南亚也很常见。疟疾种类的实验室确认通常无法获得。本研究旨在通过使用恶性疟原虫抗疟药物来寻找治疗这两种疟疾的替代方案。2004年6月至2005年5月，98例间日疟原虫患者随机接受蒿甲醚-本芴醇（n = 47）或氯喹（n = 51）治疗。两种治疗后，15毫克伯氨喹超过14天。不良事件和临床及寄生虫学结果记录显示，两组相似。蒿甲醚-本芴醇组治愈率为97.4%，氯喹组治愈率为100%。我们的结论是，蒿甲醚-苯芴醇和伯氨喹的组合是耐受性良好的，有效的氯喹和伯氨喹，并可以作为一种替代方案治疗间日疟，特别是在恶性疟原虫和间日疟的混合感染不能被排除的情况下。
Chloroquine remains the drug of choice for the treatment of vivax malaria in Thailand. Mixed infections of falciparum and vivax malaria are also common in South-East Asia. Laboratory confirmation of malaria species is not generally available. This study aimed to find alternative regimens for treating both malaria species by using falciparum antimalarial drugs. From June 2004 to May 2005, 98 patients with Plasmodium vivax were randomly treated with either artemether-lumefantrine (n = 47) or chloroquine (n = 51). Both treatments were followed by 15 mg of primaquine over 14 days. Adverse events and clinical and parasitological outcomes were recorded and revealed similar in both groups. The cure rate was 97.4% for the artemether-lumefantrine treated group and 100% for the chloroquine treated group. We concluded that the combination of artemether-lumefantrine and primaquine was well tolerated, as effective as chloroquine and primaquine, and can be an alternative regimen for treatment of vivax malaria especially in the event that a mixed infection of falciparum and vivax malaria could not be ruled out.