Expression of vascular endothelial growth factor-C and the relationship between lymphangiogenesis and lymphatic metastasis in colorectal cancer
Expression of vascular endothelial growth factor-C and the relationship between lymphangiogenesis and lymphatic metastasis in colorectal cancer
复制标题
DOI：
10.3748/wjg.v10.i22.3261
复制
发表时间：
2004-11-15
影响因子：
4.3
通讯作者：
Ma, Hong-Jun
中科院分区：
文献类型：
--
作者：
Jia, Yi-Tao;Li, Zhong-Xin;Ma, Hong-Jun
目的：探讨结直肠癌中血管内皮生长因子-C(VEGF-C)的表达及其与淋巴管生成、淋巴结转移的关系。方法：随机选取结直肠癌患者56例。免疫组化法检测VEGF-C表达，酶组织化学法检测淋巴管染色。结果：66.7%（37/56）患者有VEGF-C表达。在VEGF-C阳性和阴性患者中，淋巴管密度分别为25.16+/-7.52和17.14+/-7.22（P
AIM: To investigate the expression of vascular endothelial growth factor-C (VEGF-C) and the relationship between VEGF-C and lymphangiogenesis, lymph node metastasis in colorectal cancer.METHODS: Fifty six cases of colorectal cancer were selected randomly. Expression of VEGF-C was detected by immunohistochemistry, and lymphatic vessels were stained by enzyme histochemical method.RESULTS: VEGF-C expression was found in 66.7% (37/56) patients. In VEGF-C positive and negative patients, the lymphatic vessel density was 25.16 +/- 7.52 and 17.14 +/- 7.22, respectively (P