Green and Smart: Hydrogels To Facilitate Independent Practical Learning
Green and Smart: Hydrogels To Facilitate Independent Practical Learning
复制标题
绿色智能：水凝胶促进独立实践学习
DOI：
10.1021/acs.jchemed.7b00235
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发表时间：
2017
影响因子：
3
通讯作者：
G. A. Hurst
中科院分区：
文献类型：
--
作者：
G. A. Hurst
开发了一个实验室实验，使学生能够研究智能水凝胶在靶向药物递送中的潜在应用。这对学生来说是一个挑战，因为处理交联剂（如戊二醛）的风险极高。京尼平是一种安全的绿色替代品，它与壳聚糖和聚乙烯醇结合形成pH敏感的水凝胶。在这个以问题为基础的学习小项目中，学生可以研究该系统的溶胀行为，振荡功能，凝胶化，荧光，光学和释放特性。在本科化学学位课程的第三年的学生已经成功地进行了这个实验室实验作为一个基于问题的学习迷你项目的一部分。
A laboratory experiment was developed to enable students to investigate the use of smart hydrogels for potential application in targeted drug delivery. This is challenging for students to explore practically because of the extremely high risks of handling cross-linking agents such as glutaraldehyde. Genipin is a safe and green alternative that has been combined with chitosan and poly(vinyl alcohol) to form a pH-sensitive hydrogel. In this problem-based learning mini-project, students can study the swelling behaviors, oscillatory functionality, gelation, fluorescence, optical, and release properties of this system. Students in the third year of an undergraduate chemistry degree program have successfully conducted this laboratory experiment as part of a problem-based learning mini-project.