Biocompatible Polymeric Analogues of DMSO Prepared by Atom Transfer Radical Polymerization.
Biocompatible Polymeric Analogues of DMSO Prepared by Atom Transfer Radical Polymerization.
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DOI：
10.1021/acs.biomac.6b01553
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发表时间：
2017-02-13
影响因子：
6.2
通讯作者：
Matyjaszewski K
中科院分区：
文献类型：
--
作者：
Li S;Chung HS;Simakova A;Wang Z;Park S;Fu L;Cohen-Karni D;Averick S;Matyjaszewski K
本文报道了用原子转移自由基聚合（ATRP）合成亚砜基水溶性聚合物聚（2-（甲基亚磺酰基）丙烯酸乙酯）（polyMSEA）的方法。使用相对低量的铜催化剂（1000或100 ppm）合成了定义明确的线性聚合物。通过“臂优先”方法或“核优先”方法使用可生物降解的β-环糊精核合成了两种类型的星星聚合物。通过差示扫描量热法（DSC）测定线性聚合物（16 ℃）和星星聚合物（32 ℃）的玻璃化转变温度。聚（MSEA）的低临界溶解温度（LCST）估计为约。通过外推一系列具有NIPAM的共聚物的LCST来确定140 °C下的温度。细胞毒性试验表明，线性和星星聚合物具有低毒性，即使在浓度高达3 mg/mL时。
The synthesis of a sulfoxide-based water-soluble polymer, poly(2-(methylsulfinyl)ethyl acrylate) (polyMSEA), a polymeric analogue of DMSO, by atom transfer radical polymerization (ATRP) is reported. Well-defined linear polymers were synthesized using relatively low amounts of copper catalyst (1000 or 100 ppm). Two types of star polymers were synthesized by either an “arm-first” approach or a “core-first” approach using a biodegradable β-cyclodextrin core. The glass transition temperatures of both the linear polymer (16 °C) and star polymer (32 °C) were determined by differential scanning calorimetry (DSC). The lower critical solution temperature (LCST) of poly(MSEA) was estimated to be ca. 140 °C by extrapolating the LCST of a series of copolymers with NIPAM. Cytotoxicity tests revealed that both the linear and star polymers have low toxicity, even at concentrations up to 3 mg/mL.