Soy protein isolate does not affect ellagitannin bioavailability and urolithin formation when mixed with pomegranate juice in humans.
Soy protein isolate does not affect ellagitannin bioavailability and urolithin formation when mixed with pomegranate juice in humans.
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DOI：
10.1016/j.foodchem.2015.08.099
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发表时间：
2016-03
期刊：
影响因子：
8.8
通讯作者：
Jieping Yang;Ru-po Lee;S. Henning;G. Thames;Mark Hsu;Hei ManLam;D. Heber;Zhaoping Li
中科院分区：
文献类型：
--
作者：
Jieping Yang;Ru-po Lee;S. Henning;G. Thames;Mark Hsu;Hei ManLam;D. Heber;Zhaoping Li
我们研究了混合大豆分离蛋白和石榴汁 (PJ) 对健康志愿者中鞣花单宁 (ET) 生物利用度和代谢的影响。十八名健康志愿者单独食用石榴汁或与大豆分离蛋白 (PJSP) 预混合的石榴汁。测量血浆鞣花酸（EA）和尿液尿石素的浓度。两种干预措施之间 6 小时内血浆 EA 没有显着差异。虽然服用 PJSP 后血浆 EA 的最大浓度略低于服用 PJ 后的水平，但 EA 在血浆中的保留时间更长，消除半衰期1/2Eat 为 1.36 ± 0.59，而服用 PJSP 和 PJ 的消除半衰期分别为 1.06 ± 0.47 小时。两种干预措施之间的尿液尿石素 A、B 和 C 没有显着差异。总之，预混合大豆分离蛋白和石榴汁不会影响健康志愿者中石榴 ET 的生物利用度或代谢。
We investigated the effect of mixing soy protein isolate and pomegranate juice (PJ) on the bioavailability and metabolism of ellagitannins (ETs) in healthy volunteers. Eighteen healthy volunteers consumed PJ alone or PJ premixed with soy protein isolate (PJSP). The concentration of plasma ellagic acid (EA) and urine urolithins was measured. There was no significant difference in plasma EA over a 6-h period between the two interventions. While the maximum concentration of plasma EA after PJSP consumption was slightly but significantly lower than after PJ consumption, EA remained in the plasma longer with an elimination half-lifet1/2Eat 1.36 ± 0.59 versus 1.06 ± 0.47 h for PJSP and PJ consumption, respectively. Urinary urolithin A, B and C was not significantly different between the two interventions. In conclusion, premixing soy protein isolate and PJ did not affect the bioavailability or the metabolism of pomegranate ETs in healthy volunteers.