Production of reversible hyperadrenocortinism in rats by prolonged administration of cortisone.
Production of reversible hyperadrenocortinism in rats by prolonged administration of cortisone.
复制标题
长期给予可的松可在大鼠中产生可逆性肾上腺皮质机能亢进症。
作者：
Charles A. Winter;Robert H. Silber;H. Stoerk
在使用可的松治疗类风湿性关节炎和相关疾病时（Hench、Kendall、Slocumb和Polley，1949; Hench、Slocumb、巴恩斯、Smith、Polley和Kendall，1949），至少在一些长期治疗的病例中可能出现肾上腺皮质素过多症的体征。在一小部分接受可的松治疗的患者中观察到由一种或多种库欣综合征表现组成的反应（Sprague，1949）。因此，确定每天给予大剂量可的松会在动物中产生什么样的肾上腺皮质素过多症体征，特别是在停止激素治疗后观察到的效应是否可逆，是很有意义的。材料和方法本研究中使用的动物为雄性Holtzman大鼠，所有动物均为同一批货物，体重在180和210 gm之间。将动物圈养在单独的笼中，并饲喂饲料，随意饮水。
With the use of cortisone in the treatment of rheumatoid arthritis and allied conditions (Hench, Kendall, Slocumb and Polley, 1949; Hench, Slocumb, Barnes, Smith, Polley and Kendall, 1949), signs of hyperadrenocortinism may be expected in at least some cases treated over a prolonged period of time. Reactions consisting of one or more of the manifestations of Cushing’s syndrome have been observed in a small percentage of patients treated with cortisone (Sprague, 1949). It was therefore of interest to determine in animals what signs of hyperadrenocortinism could be produced by daily administration of large doses of cortisone, and particularly whether the effects observed were reversible after cessation of treatment with the hormone. MATERIALS AND METHODS The animals used in this study were male Holtzman rats, all of the same shipment and weighing between 180 and 210 gm. The animals were housed in individual cages and fed a stock diet, with water ad libitum.