Reduction in murine acute GVHD severity by human gingival tissue-derived mesenchymal stem cells via the CD39 pathways
Reduction in murine acute GVHD severity by human gingival tissue-derived mesenchymal stem cells via the CD39 pathways
复制标题
人牙龈组织来源的间充质干细胞通过 CD39 途径减轻小鼠急性 GVHD 的严重程度
DOI：
10.1038/s41419-018-1273-7
复制
发表时间：
2019-01-08
影响因子：
9
通讯作者：
Lu, Ling
中科院分区：
文献类型：
--
作者：
Ni, Xuhao;Xia, Yongxiang;Lu, Ling
人牙龈组织源性间充质干细胞（GMSCs）是治疗自身免疫性疾病的一种可获得的间充质干细胞（MSCs）来源。在这里，我们在两种不同的小鼠模型中展示了人类GMSCs可以预防和治疗急性移植物抗宿主病（GVHD）。我们的研究结果表明，除了在体外和体内表现出抑制功能外，GMSCs还可能调节Tregs向Th1和/或th17样细胞的转化，并稳定Foxp3的表达。此外，gmsc介导的急性GVHD的预防依赖于CD39信号，CD39信号在Tregs的功能和稳定性中发挥重要作用。最后，我们还观察到与BMSCs或ASCs相比，GMSCs的保护能力更强，扩增能力更强。这些结果表明，人类GMSCs具有用于治疗GVHD的潜力。
Human gingival tissue-derived mesenchymal stem cells (GMSCs) present an accessible source of mesenchymal stem cells (MSCs) for treating autoimmune diseases. Here we show that human GMSCs can prevent and treat acute graft-versus-host disease (GVHD) in two different mouse models. Our results indicate that besides exhibiting suppressive function in vitro and in vivo, GMSCs may also regulate the conversion of Tregs to Th1 and/or Th17-like cells, as well as stabilize Foxp3 expression. Furthermore, GMSC-mediated prevention of acute GVHD was dependent on CD39 signaling that play an important role in the function and stability of Tregs. Finally, we also observed stronger protective ability of GMSCs with greater expansion ability compared with BMSCs or ASCs. These results indicate that human GMSCs have the potential to be used to treat GVHD.