Mechanical Ventilation Induces an Inflammatory Response in Preinjured Lungs in Late Phase of Sepsis.
Mechanical Ventilation Induces an Inflammatory Response in Preinjured Lungs in Late Phase of Sepsis.
复制标题
机械通气在脓毒症晚期诱导损伤前肺部的炎症反应。
DOI：
10.1155/2015/364020
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发表时间：
2015
影响因子：
--
通讯作者：
Wu Q
中科院分区：
文献类型：
--
作者：
Xuan W;Zhou Q;Yao S;Deng Q;Wang T;Wu Q
机械通气（MV）可通过增加细胞因子释放和增加肺泡完整性的损害来放大损伤前肺中的肺特异性炎症反应。在这项研究中，我们验证了一个假设，即MV在肺损伤后的不同时间点对炎症反应产生不同的负面影响。采用盲肠结扎穿孔术（CLP）建立大鼠基础性肺损伤模型。在MV期间监测包括血气在内的生理指标，并在每次实验后评估样品。低VT（潮气量）MV引起脓毒症诱导的肺损伤后第1天和第4天细胞因子释放和组织损伤轻微增加，而两个中度通气VT组中肺细胞因子释放被放大。有趣的是，在接受低VT MV的两组大鼠中，我们发现炎症细胞的浸润仅在CLP后第4天才有意义。蛋白渗漏的显著升高表明在CLP后第4天接受中度VT MV的大鼠中肺泡完整性的损害，与肺泡的结构损伤相关。我们的研究表明，在脓毒症后期，预损伤的肺对机械MV更敏感，这种情况可能是不同免疫状态的结果。
Mechanical ventilation (MV) may amplify the lung-specific inflammatory response in preinjured lungs by elevating cytokine release and augmenting damage to the alveolar integrity. In this study, we test the hypothesis that MV exerts different negative impacts on inflammatory response at different time points of postlung injury. Basic lung injury was induced by cecal ligation and puncture (CLP) surgery in rats. Physiological indexes including blood gases were monitored during MV and samples were assessed following each experiment. Low V T (tidal volume) MV caused a slight increase in cytokine release and tissue damage at day 1 and day 4 after sepsis induced lung injury, while cytokine release from the lungs in the two moderately ventilated V T groups was amplified. Interestingly, in the two groups where rats received low V T MV, we found that infiltration of inflammatory cells was only profound at day 4 after CLP. Marked elevation of protein leakage indicated a compromise in alveolar integrity in rats that received moderate V T MV at day 4 following CLP, correlating with architectural damage to the alveoli. Our study indicates that preinjured lungs are more sensitive to mechanical MV at later phases of sepsis, and this situation may be a result of differing immune status.
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DOI：
10.1186/cc7911
发表时间：
2009
期刊：
Critical care (London, England)
影响因子：
--
作者：
Kneyber MC;Gazendam RP;Niessen HW;Kuiper JW;Dos Santos CC;Slutsky AS;Plötz FB
通讯作者：
Plötz FB
DOI：
10.1186/cc8230
发表时间：
2010
期刊：
Critical care (London, England)
影响因子：
--
作者：
Determann RM;Royakkers A;Wolthuis EK;Vlaar AP;Choi G;Paulus F;Hofstra JJ;de Graaff MJ;Korevaar JC;Schultz MJ
通讯作者：
Schultz MJ
DOI：
10.1152/ajplung.00097.2011
发表时间：
2012-04-01
影响因子：
4.9
作者：
Campos, Renata;Massola Shimizu, Maria Heloisa;Seguro, Antonio Carlos
通讯作者：
Seguro, Antonio Carlos
影响因子：
3.3
作者：
Nakamura, T;Malloy, J;Veldhuizen, R
通讯作者：
Veldhuizen, R
影响因子：
4.4
作者：
Coelho, Ana L.;Schaller, Matthew A.;Kunkel, Steven L.
通讯作者：
Kunkel, Steven L.