The Obsessive Compulsive Scale of the Child Behavior Checklist predicts obsessive-compulsive disorder: a receiver operating characteristic curve analysis
The Obsessive Compulsive Scale of the Child Behavior Checklist predicts obsessive-compulsive disorder: a receiver operating characteristic curve analysis
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DOI：
10.1111/j.1469-7610.2005.01465.x
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发表时间：
2006-02-01
影响因子：
7.6
通讯作者：
Todd, RD
中科院分区：
文献类型：
--
作者：
Hudziak, JJ;Althoff, RR;Todd, RD
背景：本研究的目的是确定儿童行为检查表（CBCL）中强迫量表（OCS）的分数，以筛查儿童强迫症（OCD），并严格测试单个切点的特异性和敏感性。方法：对 61 名临床确定的 OCD 患者、64 名临床对照和 73 名普通人群对照的数据进行受试者工作特征 (ROC) 曲线分析，以确定 CBCL-OCS 的最佳总分，以预测儿童确诊的 OCD。使用 ROC 确定的截止值，将该分数应用于全国 2460 名 4-18 岁单胎儿童的 CBCL 数据样本以及来自三个大型一般人群双胞胎样本的 20,016 名 7-18 岁儿童的 CBCL 数据，以确定一般人群中的估计患病率。结果：与临床对照相比，使用 CBCL-OCS 评分 5 表明曲线下面积 (AUC) 为 0.88，具有高敏感性 (92%) 和中等特异性 (67%)。与一般人群对照相比，AUC 为 0.96，具有高敏感性 (92%) 和特异性 (89%)。在双胞胎样本中，CBCL-OCS 分数高于此分界点的参与者数量为 2.3-7.1%。结论：这些研究结果表明，CBCL 的 OCS 可能提供一种高效的儿童强迫症筛查方法，并且儿童强迫症的患病率可能被低估，因此需要进一步研究筛查儿童的这种情况。
Background: The purpose of this study was to determine a score on the Obsessive Compulsive Scale (OCS) from the Child Behavior Checklist (CBCL) to screen for obsessive compulsive disorder (OCD) in children and to rigorously test the specificity and sensitivity of a single cutpoint. Methods: A receiver operating characteristic (ROC) curve analysis was applied to data from 61 patients with clinically determined OCD, 64 clinical controls and 73 general population controls to determine the best sum score on the CBCL-OCS to predict confirmed OCD in children. Using the ROC-determined cutoff, this score was applied to a national sample of CBCL data from 2460 singleton children ages 4-18 and to 20,016 children ages 7-18 from three large general population twin samples to determine the estimated prevalence in the general population. Results: Using a CBCL-OCS score of 5 demonstrated an area under the curve (AUC) of .88 with high sensitivity (92%) and moderate specificity (67%) compared to clinical controls. Compared to the general population controls, the AUC was .96 with high sensitivity (92%) and specificity (89%). In the twin samples, the number of participants with CBCL-OCS scores above this cutpoint was 2.3-7.1%. Conclusions: These findings suggest that the OCS of the CBCL may provide a highly effective way to screen for childhood OCD, and that the prevalence of childhood OCD may have been underestimated, thus prompting the need for further research into screening children for this condition.