Prevalence and genetic architecture of child behavior checklist-juvenile bipolar disorder
Prevalence and genetic architecture of child behavior checklist-juvenile bipolar disorder
复制标题
DOI：
10.1016/j.biopsych.2005.03.024
复制
发表时间：
2005-10-01
影响因子：
10.6
通讯作者：
Boomsma, DI
中科院分区：
文献类型：
--
作者：
Hudziak, JJ;Althoff, RR;Boomsma, DI
背景：关于如何最好地描述青少年双相情感障碍（JBD）尚未达成共识。几个小组已经表明，儿童行为检查表（CBCL）中的注意问题（AP）、攻击行为（AGG）和焦虑抑郁（AD）症状可能符合DSM-JBD的标准。我们的目的是使用基于大量人群的双胞胎样本来评估CBCL-JBD（AP、AGG和AD异常）表型的患病率和遗传结构，并将这些数据与仅CBCL-AP综合征异常的儿童进行比较。方法：将结构方程模型（SEM）应用于5418、3562和1971对7岁、10岁和12岁的荷兰双胞胎的CBCL数据。结果：在每个年龄段，CBCL-JBD表型发生在大约1%的儿童中。在符合CBCL-AP表型标准的儿童中（类似于5%），13%至20%也符合CBCL-JBD标准。CBCL-JBD的最佳SEM包括加性遗传因子、共有环境因子和独特环境因子。结论：这些数据提示CBCL存在问题。由于遗传和共同的环境因素，CBCL-JBD表现出家族聚集性。
Background: No consensus has been reached yet on bow best to characterize children with juvenile bipolar disorder (JBD). Several groups have shown that children on the attention problems (AP), aggressive behavior (AGG), and anxious-depressed (AD) syndromes of the Child Behavior Checklist (CBCL) are likely to meet criteria for DSM-JBD. We aimed to use a large population-based twin sample to evaluate the prevalence and genetic architecture of the CBCL-JBD(deviant on AP, AGG, and AD)phenotype and compare these data to children who are deviant on just the CBCL-AP syndrome.Methods: Structural equation modeling (SEM) was applied to CBCL data from 5418, 3562, and 1971 Dutch twin pairs at ages 7, 10, and 12 years.Results: The CBCL-JBD phenotype occurs in similar to 1% of children at each age. Among the children who meet criteria for the CBCL-AP phenotype (similar to 5%), between 13 and 20% also meet criteria for CBCL-JBD. The best SEM for CBCL-JBD includes additive genetic, shared and unique environmental factors.Conclusions: These data suggest that CBCL problems. CBCL-JBD shows familial aggregation due to both genetic and shared environmental factors.