Sheet-beam geometry for in vivo fluorescent x-ray computed tomography: proof-of-concept experiment in molecular imaging
Sheet-beam geometry for in vivo fluorescent x-ray computed tomography: proof-of-concept experiment in molecular imaging
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DOI：
10.1364/ol.33.002494
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发表时间：
2008-11-01
期刊：
影响因子：
3.6
通讯作者：
Dilmanian, F. Avraham
中科院分区：
文献类型：
--
作者：
Huo, Qingkai;Yuasa, Tetsuya;Dilmanian, F. Avraham
我们提出了一种荧光 X 射线计算机断层扫描方法，使用具有入射片状光束的探测器阵列，旨在提供高灵敏度和良好空间分辨率的分子成像。在这项研究中，我们通过使用单色同步加速器 X 射线的初步成像系统对丙烯酸模型和正常小鼠大脑进行成像，证明了这一概念的可行性并研究了其成像特性，包括空间分辨率和对比度分辨率以及定量性。 (C) 2008 美国光学学会
We propose a fluorescent x-ray computed tomography method using an array of detectors with an incident sheet beam, aimed at providing molecular imaging with high sensitivity and good spatial resolution. In this study, we prove the feasibility of this concept and investigate its imaging properties, including spatial and contrast resolutions and quantitativeness, by imaging an acrylic phantom and a normal mouse brain using a preliminary imaging system with monochromatic synchrotron x rays. (C) 2008 Optical Society of America