N-heterocyclic carbene catalysed asymmetric cross-benzoin reactions of heteroaromatic aldehydes with trifluoromethyl ketones
N-heterocyclic carbene catalysed asymmetric cross-benzoin reactions of heteroaromatic aldehydes with trifluoromethyl ketones
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DOI：
10.1039/c0cc02013c
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发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Raabe, Gerhard
中科院分区：
文献类型：
--
作者：
Enders, Dieter;Grossmann, Andre;Raabe, Gerhard
一种新型三唑盐衍生的n-杂环羰基化合物可催化杂芳醛与各种三氟甲基酮的不对称交叉苯甲酮型反应，产率为69 ~ 96%，对映选择性为39 ~ 85%。通过再结晶可以达到99%的ee。
A new triazolium salt derived N-heterocyclic carbene catalyses an asymmetric cross-benzoin-type reaction of heteroaromatic aldehydes and various trifluoromethyl ketones in good to excellent yields (69-96%) and moderate to good enantio-selectivities (ee = 39-85%). Up to 99% ee can be achieved by recrystallisation.