Effect of aerobic training on plasma levels and subcutaneous abdominal adipose tissue gene expression of adiponectin, leptin, interleukin 6, and tumor necrosis factor α in obese women
Effect of aerobic training on plasma levels and subcutaneous abdominal adipose tissue gene expression of adiponectin, leptin, interleukin 6, and tumor necrosis factor α in obese women
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DOI：
10.1016/j.metabol.2006.06.008
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发表时间：
2006-10-01
影响因子：
9.8
通讯作者：
Stich, Vladimir
中科院分区：
文献类型：
--
作者：
Polak, Jan;Klimcakova, Eva;Stich, Vladimir
脂肪组织分泌的脂肪细胞因子被认为在肥胖相关并发症的发展中发挥作用。有规律的有氧运动已被证明可以降低肥胖受试者发生代谢并发症的风险。本研究的目的是探讨有氧训练对肥胖妇女腹部皮下脂肪组织（SCAAT）基因表达和几种脂肪细胞因子血浆水平的影响。25名肥胖久坐的绝经前女性（体重指数，32.18 +/- 3.17 kg/m2）进行了为期12周的有氧运动计划，频率为5天/周，强度相当于个人最大耗氧量（VO（2）max）的50%，包括每周2次有监督的有氧运动和每周3次家庭运动，基于自行车测力计的运动。在有氧训练前后，测量VO 2 max和身体成分，并获得血浆和SCAAT活检样本（在一个8人的亚组中），用于测定脂肪细胞因子（瘦素、脂联素、白细胞介素6、肿瘤坏死因子a）的血浆和信使RNA水平。有氧训练导致受试者的VO（2）max增加12.8%（24.6 +/- 3.9 vs 27.7 +/- 4.8 mL（.）min（-1）（.）kg（-1），P
Adipocytokines secreted by adipose tissue are suggested to play a role in the development of obesity-related complications. Regular aerobic exercise has been shown to reduce the risk of metabolic complications in obese subjects. The aim of this study was to investigate the effect of aerobic training on gene expression in subcutaneous abdominal adipose tissue (SCAAT) and on plasma levels of several adipocytokines in obese women. Twenty-five obese sedentary premenopausal women (body mass index, 32.18 +/- 3.17 kg/m(2)) underwent a 12-week aerobic exercise program, with a frequency of 5 d/wk and intensity corresponding to 50% of individual maximal oxygen consumption (VO(2)max) consisting of 2 sessions per week of supervised aerobic exercise and 3 sessions per week of home-based exercise on a bicycle ergometer. Before and after the aerobic training, VO(2)max and body composition were measured and plasma and SCAAT biopsy samples (in a subgroup of 8 subjects) were obtained for determination of plasma and messenger RNA levels of adipocytokines (leptin, adiponectin, interleukin 6, tumor necrosis factor a). The aerobic training resulted in an increase of subjects' VO(2)max by 12.8% (24.6 +/- 3.9 vs 27.7 +/- 4.8 mL (.) min(-1) (.) kg(-1), P