Mechanisms of autophagy and relevant small-molecule compounds for targeted cancer therapy
Mechanisms of autophagy and relevant small-molecule compounds for targeted cancer therapy
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自噬机制及相关小分子化合物用于癌症靶向治疗
DOI：
10.1007/s00018-018-2759-2
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发表时间：
2018
影响因子：
8
通讯作者：
Liu Bo
中科院分区：
文献类型：
--
作者：
Zhang Jin;Wang Guan;Zhou Yuxin;Chen Yi;Ouyang Liang;Liu Bo
自噬是一种进化保守的多步骤溶酶体降解过程，用于清除受损或多余的蛋白质和细胞器。越来越多的研究表明，自噬与多种类型的癌症密切相关；然而，其抑癌或促癌的Janus作用仍有待阐明。在这篇综述中，我们重点总结自噬在不同类型的癌症中的上下文依赖的作用及其复杂的分子机制。此外，我们还讨论了一系列针对自噬相关蛋白或自噬过程的小分子化合物，以用于潜在的癌症治疗。综上所述，这些发现将为利用自噬和相关小分子化合物的复杂机制作为潜在的抗癌药物来改进靶向癌症治疗提供新的线索。
Autophagy is an evolutionarily conserved, multi-step lysosomal degradation process for the clearance of damaged or superfluous proteins and organelles. Accumulating studies have recently revealed that autophagy is closely related to a variety of types of cancer; however, elucidation of its Janus role of either tumor-suppressive or tumor-promoting still remains to be discovered. In this review, we focus on summarizing the context-dependent role of autophagy and its complicated molecular mechanisms in different types of cancer. Moreover, we discuss a series of small-molecule compounds targeting autophagy-related proteins or the autophagic process for potential cancer therapy. Taken together, these findings would shed new light on exploiting the intricate mechanisms of autophagy and relevant small-molecule compounds as potential anti-cancer drugs to improve targeted cancer therapy.