Nizatidine Ameliorates Slow Transit Constipation in Parkinson's Disease
Nizatidine Ameliorates Slow Transit Constipation in Parkinson's Disease
复制标题
尼扎替丁可改善帕金森病的慢传输性便秘
DOI：
10.1111/jgs.13279
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发表时间：
2015
影响因子：
6.3
通讯作者：
Yasuo Suzuki
中科院分区：
文献类型：
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作者：
R. Sakakibara;H. Doi;M. Sato;S. Hirai;Tohru Masaka;M. Kishi;Y. Tsuyusaki;Akihiko Tateno;F. Tateno;Y. Aiba;Tsuyoshi Ogata;Yasuo Suzuki
致编辑：便秘（慢传输型和肛门直肠型）是帕金森病（PD）中最常见的非运动性疾病之一。肌间神经丛中出现神经元变性和α-突触核蛋白阳性路易体。便秘导致急性假性肠梗阻，干扰左旋多巴的吸收，引发恶性综合征，并且可能比运动障碍更早出现。因为慢传输型便秘对左旋多巴没有反应，所以已经尝试了附加治疗，效果各不相同。尼扎替丁，作用于组胺H2受体，给药前后的结肠传输时间（CTT）测试的结果。入选标准为PD和胃肠道（GIT）症状（上：恶心，餐后腹胀;下：每周排便<3次，排便困难）（12名参与者主诉便秘）。个别-
To the Editor: Constipation (slow transit and anorectal types) is one of the most common nonmotor disorders in Parkinson’s disease (PD). Neuronal degeneration with alpha-synuclein-positive Lewy bodies appears in the myenteric plexus. Constipation leads to emergency intestinal pseudoobstruction, interferes with levodopa absorption, triggers malignant syndrome, and can appear earlier than motor disorder. Because slow-transit constipation is not responsive to levodopa, add-on therapies have been tried, with variable benefits. The results of a colonic transit time (CTT) test before and after administration of nizatidine, which acts on histamine H2 receptors, is presented. Inclusion criteria were PD and gastrointestinal tract (GIT) symptoms (upper: nausea, postprandial bloating; lower: bowel movement <3 times a week, difficult defecation) (12 participants complained of constipation). Individ-
尼扎替丁改善伴有胃排空障碍的功能性消化不良患者的临床症状和胃排空
DOI：
--
发表时间：
2011
期刊：
影响因子：
--
作者：
Futagami S;Shimpuku M;Kodaka Y;et al.
通讯作者：
et al.