QUANTITATIVE-ANALYSIS OF THE ORAL COMPLICATIONS OF ANTILEUKEMIA CHEMOTHERAPY
QUANTITATIVE-ANALYSIS OF THE ORAL COMPLICATIONS OF ANTILEUKEMIA CHEMOTHERAPY
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DOI：
10.1016/0030-4220(86)90258-6
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发表时间：
1986-12-01
期刊：
影响因子：
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通讯作者：
KEATING, MJ
中科院分区：
文献类型：
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作者：
DREIZEN, S;MCCREDIE, KB;KEATING, MJ
1500 名接受急性白血病治疗的患者中，近一半 (46.9%) 在住院期间的某个时间出现了化疗相关的口腔感染、口腔粘膜炎和/或口腔出血。感染发生率 34.2%，粘膜炎发生率 16.3%，出血发生率 13.6%，与该机构之前报告的小群体患者发生率分别在 1.3% 至 3.1% 范围内。口腔破坏反映了抗白血病药物的细胞毒性、骨髓抑制和免疫抑制特性。由于目前还没有其他方法可以替代使用强效口腔毒性药物来治疗急性白血病，因此必须通过早期识别和适当的治疗将其副作用降至最低。
Almost half of 1500 patients (46.9%) treated for acute leukemia developed chemotherapy-related oral infections, oral mucositis, and/or oral hemorrhages at some time during their hospitalization. The frequencies of 34.2% for infections, 16.3% for mucositis, and 13.6% for hemorrhages were each within 1.3% to 3.1% of those previously reported from this institution for smaller groups of patients. The stomatologic disruptions reflected the cytotoxic, myelosuppressive, and immunosuppressive properties of the antileukemia drugs. Because there are as yet no alternatives to the use of potent stomatotoxic drugs for the treatment of acute leukemia, it is essential that their side effects be kept to a minimum by early recognition and appropriate treatment.