SEXUALLY DIMORPHIC EFFECTS OF PERINATAL ALCOHOL EXPOSURE ON SOCIAL INTERACTIONS AND AMYGDALA DNA AND DOPAC CONCENTRATIONS
SEXUALLY DIMORPHIC EFFECTS OF PERINATAL ALCOHOL EXPOSURE ON SOCIAL INTERACTIONS AND AMYGDALA DNA AND DOPAC CONCENTRATIONS
复制标题
DOI：
10.1016/0892-0362(94)90026-4
复制
发表时间：
1994-07-01
影响因子：
2.9
通讯作者：
DILLINGHAM, RR
中科院分区：
文献类型：
--
作者：
KELLY, SJ;DILLINGHAM, RR
假设大鼠在大致相当于人类妊娠晚期的一段时间内接触酒精会导致社会互动以及杏仁核区域神经递质和DNA浓度的变化。酒精暴露是通过人工饲养程序完成的。在所有研究中，有两个酒精暴露组(酒精3和5g/kg/d)和两个对照组(一个人工饲养但不接触酒精，一个由水坝正常饲养)。与各自的对照组相比，男性5g/kg/天组的活跃社交活动减少，而两个女性酒精暴露组的活跃社交活动增加。与任何一个对照组相比，每天暴露于5g/kg酒精的雄性大鼠杏仁核区域的DNA浓度降低；对雌性大鼠没有影响。由于一些系统被证明只有在应激条件下才表现出酒精诱导的变化，所以在非应激和应激条件下，杏仁核区的去甲肾上腺素、多巴胺、3，4-二羟基苯乙酸(DOPAC)、5-羟色胺和5-羟基吲哚乙酸(5-HIAA)的浓度都被测量了。与任何一个对照组相比，女性高剂量组应激诱导的DOPAC浓度增加；而男性则没有影响。总而言之，出生后早期的酒精暴露改变了社会互动，改变了杏仁核区DOPAC和DNA浓度，以性二态的方式发生变化。
The hypotheses that exposure of rats to alcohol during a period roughly equivalent to the human third trimester induces changes in social interactions and neurotransmitter and DNA concentrations in the amygdala region were examined. The alcohol exposure was accomplished via an artificial rearing procedure. There were two alcohol-exposed groups (3 and 5 g/kg/day of ethanol) and two control groups (one artificially reared but not exposed to alcohol and one reared normally by dams) in all studies. Active social interactions were reduced in the male 5 g/kg/day group and increased in both female alcohol-exposed groups compared to their respective control groups. Exposure to 5 g/kg/day of alcohol reduced the DNA concentration in the amygdala region of male rats compared to either control group; there were no effects in females. Because some systems have been shown to exhibit alcohol-induced changes only under stressed conditions, noradrenaline, dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin, and 5-hydroxyindoleacetic acid (5-HIAA) concentrations were measured in the amygdala region under both nonstressed and stressed conditions. The stress-induced increase in DOPAC concentrations was enhanced in the female high dose group compared to either control group; there were no effects in males. In summary, alcohol exposure during the early postnatal period altered social interactions and DOPAC and DNA concentrations in the amygdala region in a sexually dimorphic manner.