Factors associated with biomedical research participation within community-based samples across 3 National Cancer Institute-designated cancer centers
Factors associated with biomedical research participation within community-based samples across 3 National Cancer Institute-designated cancer centers
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DOI：
10.1002/cncr.32487
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发表时间：
2020-01-07
期刊：
影响因子：
6.2
通讯作者：
Gage-Bouchard, Elizabeth A.
中科院分区：
文献类型：
--
作者：
Barrett, Nadine J.;Rodriguez, Elisa M.;Gage-Bouchard, Elizabeth A.
背景：让不同人群参与生物医学研究，包括生物医学捐赠，仍然是一个全国性的挑战。这项研究考察了与邀请参与生物医学研究、未来参与生物医学研究的意向以及参与生物医学研究和生物样品捐赠的相关因素，这些样本分布在三个不同的地理区域，以不同的语言为基础。方法三个国家癌症研究所指定的癌症中心参与社区合作，开发和实施人口健康评估，在各自的集水区对4343名参与者进行方便抽样。使用了数据协调、多重归因和多变量Logistic建模。结果与白人相比，非洲裔美国人、西班牙裔/拉丁裔和其他少数族裔群体更有可能获得参与生物医学研究的机会。获得护理、癌症病史、教育水平、调查语言、出生地和农村居住地也影响了参与生物医学研究的机会、意图和实际参与。结论传统上服务不足的种族和民族群体报告了参与生物医学研究的更高的机会和兴趣。良好的社区伙伴关系和围绕生物医学研究的长期社区参与导致每个地点都获得了不同的样本，这可能在一定程度上解释了目前的研究结果。然而，这项研究表明，通过创新和量身定做的方法，建立信任和使生物医学研究参与多样化的持续需要。国家癌症研究所指定的癌症中心有可能通过社区伙伴关系和参与增加不同方面参与生物医学研究的机会。还有其他工作要做，以确定和解决参与临床试验和捐赠生物样品用于研究的系统和个人层面的障碍。
Background Engaging diverse populations in biomedical research, including biospecimen donation, remains a national challenge. This study examined factors associated with an invitation to participate in biomedical research, intent to participate in biomedical research in the future, and participation in biomedical research and biospecimen donation among a diverse, multilingual, community-based sample across 3 distinct geographic areas. Methods Three National Cancer Institute-designated cancer centers engaged in community partnerships to develop and implement population health assessments, reaching a convenience sample of 4343 participants spanning their respective catchment areas. Data harmonization, multiple imputation, and multivariable logistic modeling were used. Results African Americans, Hispanic/Latinos, and other racial minority groups were more likely to be offered opportunities to participate in biomedical research compared to whites. Access to care, history of cancer, educational level, survey language, nativity, and rural residence also influenced opportunity, intent, and actual participation in biomedical research. Conclusions Traditionally underserved racial and ethnic groups reported heightened opportunity and interest in participating in biomedical research. Well-established community partnerships and long-standing community engagement around biomedical research led to a diverse sample being reached at each site and may in part explain the current study findings. However, this study illustrates an ongoing need to establish trust and diversify biomedical research participation through innovative and tailored approaches. National Cancer Institute-designated cancer centers have the potential to increase opportunities for diverse participation in biomedical research through community partnerships and engagement. Additional work remains to identify and address system-level and individual-level barriers to participation in both clinical trials and biospecimen donation for research.