Benzidine dihydrochloride: toxicological assessment in mice during chronic exposures.
Benzidine dihydrochloride: toxicological assessment in mice during chronic exposures.
复制标题
二盐酸联苯胺：慢性暴露期间小鼠的毒理学评估。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
C. Frith
中科院分区：
文献类型：
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作者：
N. Littlefield;C. Nelson;C. Frith
虽然联苯胺在人类中被认为是膀胱癌的致癌物，在实验动物中被认为是肝癌的致癌物，但它的毒理效应似乎延伸到了其他几个终点。这种具有重要经济意义的化学品是200多种染料的基础，并在制造中广泛使用。在一项持续33个月的慢性寿命研究中，BALB/c雄性和C57BL/6雌性杂交F1杂交(遗传同质性)和单杂交(遗传异质性)小鼠的雌鼠饮用浓度分别为0、20、30、40、60、80和120ppm的联苯胺二盐酸盐，雄鼠为0、30、40、60、80、120和160ppm。当动物死亡或奄奄一息时，它们会被从研究中移走。除了肝细胞癌，还有几个其他的毒理学终点似乎与联苯胺的使用有关。脾的色素沉着、肝细胞学改变、胆管增生、骨髓巨核细胞增多症、脑空泡化、哈德氏腺瘤、卵巢萎缩和子宫血管瘤均呈剂量-反应趋势。此外，在肺肿瘤发生时间和网状细胞肉瘤死亡时间方面也注意到了剂量相关效应。
Although benzidine is recognized as a bladder carcinogen in humans and a liver carcinogen in laboratory animals, its toxicological effects appear to be extended to several other endpoints. This economically important chemical is the base for over 200 dyes and is used extensively in manufacturing. In a chronic lifespan study lasting 33 months, both sexes of F1 hybrid (genetically homogeneous) and monohybrid cross (genetically heterogeneous) mice from BALB/c male and C57BL/6 female crosses were exposed to benzidine dihydrochloride in their drinking water at concentrations of 0, 20, 30, 40, 60, 80, and 120 ppm for the females, and 0, 30, 40, 60, 80, 120, and 160 ppm for males. Animals were removed from the study when they were dead or moribund. In addition to hepatocellular carcinomas, there were several other toxicological end-points identified that appeared to be related to the administration of benzidine. Dose-response trends were noted for pigmentation of the spleen, hepatic cytological alterations, hyperplasia of the bile ducts, megakaryocytosis of the bone marrow, vacuolization of the brain, adenoma of the Harderian gland, atrophy of the ovaries, and angioma of the uterus. Also, dose-related effects were noted with respect to time to lung tumor and time to mortality due to reticulum-cell sarcomas.