Toll-like receptor signaling and IRF transcription factors
Toll-like receptor signaling and IRF transcription factors
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DOI：
10.1080/15216540600702206
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发表时间：
2006-05-01
期刊：
影响因子：
4.6
通讯作者：
Taniguchi, Tadatsugu
中科院分区：
文献类型：
--
作者：
Honda, Kenya;Taniguchi, Tadatsugu
Interferon regulatory factors (IRFs) were originally discovered in the context of type I interferon (IFN-alpha/beta) gene induction, and subsequent studies on these transcription factors have revealed their remarkable functional diversity in regulating immune systems. Indeed, the critical involvement of IRF members in innate and adaptive immune responses has recently gained much attention, particularly with the recent discovery of Toll-like receptors (TLRs) and analyses of their critical functions in linking the innate and adaptive immune responses.
